SPO11 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPO11 at tissue level.

Tissue	GTEx Coverage	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lymph node	0%	0 / 0	3%	0.05	1 / 29
stomach	0%	0 / 359	1%	0.03	4 / 286
breast	0%	0 / 459	0%	0.08	3 / 1118
ovary	0%	0 / 180	0%	0.01	1 / 430
intestine	0%	0 / 966	0%	0.00	1 / 527
lung	0%	0 / 578	0%	0.00	2 / 1155
thymus	0%	0 / 653	0%	0.00	1 / 605
kidney	0%	0 / 89	0%	0.00	1 / 901
abdomen	0%	0 / 0	0%	0	0 / 0
adipose	0%	0 / 1204	0%	0	0 / 0
adrenal gland	0%	0 / 258	0%	0	0 / 230
bladder	0%	0 / 21	0%	0	0 / 504
blood vessel	0%	0 / 1335	0%	0	0 / 0
bone marrow	0%	0 / 0	0%	0	0 / 0
brain	0%	0 / 2642	0%	0	0 / 705
diaphragm	0%	0 / 0	0%	0	0 / 0
esophagus	0%	0 / 1445	0%	0	0 / 183
eye	0%	0 / 0	0%	0	0 / 80
gingiva	0%	0 / 0	0%	0	0 / 0
heart	0%	0 / 861	0%	0	0 / 0
liver	0%	0 / 226	0%	0	0 / 406
muscle	0%	0 / 803	0%	0	0 / 0
nasal cavity	0%	0 / 0	0%	0	0 / 0
nasopharynx	0%	0 / 0	0%	0	0 / 0
nose	0%	0 / 0	0%	0	0 / 0
pancreas	0%	0 / 328	0%	0	0 / 178
peripheral blood	0%	0 / 929	0%	0	0 / 0
placenta	0%	0 / 0	0%	0	0 / 0
prostate	0%	0 / 245	0%	0	0 / 502
skin	0%	0 / 1809	0%	0	0 / 472
spinal column	0%	0 / 0	0%	0	0 / 0
spleen	0%	0 / 241	0%	0	0 / 0
tonsil	0%	0 / 0	0%	0	0 / 45
ureter	0%	0 / 0	0%	0	0 / 1
uterus	0%	0 / 170	0%	0	0 / 459

GO_0034502	Biological process	protein localization to chromosome
GO_0007130	Biological process	synaptonemal complex assembly
GO_0007283	Biological process	spermatogenesis
GO_0001541	Biological process	ovarian follicle development
GO_0007131	Biological process	reciprocal meiotic recombination
GO_0045141	Biological process	meiotic telomere clustering
GO_0007141	Biological process	male meiosis I
GO_0000706	Biological process	meiotic DNA double-strand break processing
GO_1990918	Biological process	double-strand break repair involved in meiotic recombination
GO_0042138	Biological process	meiotic DNA double-strand break formation
GO_0048477	Biological process	oogenesis
GO_0007286	Biological process	spermatid development
GO_0007292	Biological process	female gamete generation
GO_0000228	Cellular component	nuclear chromosome
GO_0000781	Cellular component	chromosome, telomeric region
GO_0003677	Molecular function	DNA binding
GO_0003918	Molecular function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

Gene name	SPO11
Protein name	Meiotic recombination protein SPO11 (EC 5.6.2.2) (Cancer/testis antigen 35) (CT35) SPO11 initiator of meiotic double stranded breaks DNA topoisomerase (ATP-hydrolyzing) (EC 5.6.2.2)
Synonyms
Description	FUNCTION: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2. .
Accessions	Q5TCH6 Q5TCH7 ENST00000371260.8 H0YCK9 ENST00000418127.5 Q9Y5K1 ENST00000371263.8 [Q9Y5K1-1] ENST00000494972.1 ENST00000345868.8 [Q9Y5K1-2]

SPO11 report