SPIRE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046907Biological processintracellular transport
GO_0090141Biological processpositive regulation of mitochondrial fission
GO_0045087Biological processinnate immune response
GO_0030041Biological processactin filament polymerization
GO_0045010Biological processactin nucleation
GO_0048193Biological processGolgi vesicle transport
GO_0051639Biological processactin filament network formation
GO_0030036Biological processactin cytoskeleton organization
GO_0016192Biological processvesicle-mediated transport
GO_0015031Biological processprotein transport
GO_0051295Biological processestablishment of meiotic spindle localization
GO_0036089Biological processcleavage furrow formation
GO_0070649Biological processformin-nucleated actin cable assembly
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0040038Biological processpolar body extrusion after meiotic divisions
GO_0005856Cellular componentcytoskeleton
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005741Cellular componentmitochondrial outer membrane
GO_0032154Cellular componentcleavage furrow
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameSPIRE1
Protein nameSPIRE1 protein
Protein spire homolog 1 (Spir-1)
Spire type actin nucleation factor 1
SynonymsKIAA1135
SPIR1
DescriptionFUNCTION: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament . Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport . Required for asymmetric spindle positioning and asymmetric cell division during meiosis . Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis . Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage . In addition, promotes innate immune signaling downstream of dsRNA sensing . Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 . .

AccessionsENST00000309836.9
ENST00000449797.5
ENST00000410092.7 [Q08AE8-2]
ENST00000497844.6
K7EMJ7
ENST00000453447.6 [Q08AE8-5]
K7ENV1
J3KNG6
C9JYR7
ENST00000440472.6 [Q08AE8-4]
K7EQR2
ENST00000462226.1
ENST00000592156.5
Q08AE8
ENST00000409402.9 [Q08AE8-1]
Q96AS4