Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 17 studies | 46% ± 22% | |
endothelial cell | 17 studies | 29% ± 13% | |
glutamatergic neuron | 13 studies | 52% ± 25% | |
GABAergic neuron | 11 studies | 47% ± 26% | |
oligodendrocyte | 11 studies | 33% ± 12% | |
microglial cell | 10 studies | 25% ± 11% | |
oligodendrocyte precursor cell | 10 studies | 40% ± 14% | |
macrophage | 9 studies | 36% ± 12% | |
adipocyte | 8 studies | 28% ± 10% | |
fibroblast | 8 studies | 24% ± 6% | |
interneuron | 6 studies | 56% ± 26% | |
neuron | 5 studies | 38% ± 14% | |
pericyte | 5 studies | 35% ± 15% | |
retinal ganglion cell | 5 studies | 29% ± 15% | |
mast cell | 5 studies | 20% ± 4% | |
smooth muscle cell | 5 studies | 26% ± 5% | |
type I pneumocyte | 5 studies | 24% ± 4% | |
type II pneumocyte | 5 studies | 43% ± 4% | |
epithelial cell | 4 studies | 29% ± 13% | |
granule cell | 4 studies | 33% ± 5% | |
cardiac muscle cell | 4 studies | 37% ± 4% | |
myeloid cell | 4 studies | 34% ± 13% | |
club cell | 4 studies | 28% ± 6% | |
GABAergic interneuron | 3 studies | 48% ± 4% | |
progenitor cell | 3 studies | 42% ± 28% | |
squamous epithelial cell | 3 studies | 21% ± 5% | |
OFF-bipolar cell | 3 studies | 31% ± 10% | |
ON-bipolar cell | 3 studies | 31% ± 10% | |
glycinergic amacrine cell | 3 studies | 18% ± 2% | |
rod bipolar cell | 3 studies | 33% ± 10% | |
retinal pigment epithelial cell | 3 studies | 39% ± 29% | |
ependymal cell | 3 studies | 43% ± 18% | |
alveolar macrophage | 3 studies | 38% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2201.48 | 2641 / 2642 | 99% | 46.14 | 701 / 705 |
skin | 99% | 1422.70 | 1791 / 1809 | 94% | 25.24 | 446 / 472 |
breast | 100% | 1166.15 | 459 / 459 | 93% | 15.98 | 1036 / 1118 |
kidney | 100% | 1078.16 | 89 / 89 | 90% | 24.22 | 814 / 901 |
lung | 100% | 1585.64 | 576 / 578 | 88% | 12.23 | 1015 / 1155 |
esophagus | 96% | 1163.43 | 1391 / 1445 | 89% | 12.76 | 162 / 183 |
prostate | 99% | 992.22 | 243 / 245 | 85% | 10.24 | 425 / 502 |
adrenal gland | 100% | 1996.16 | 258 / 258 | 72% | 7.66 | 166 / 230 |
thymus | 99% | 805.50 | 649 / 653 | 72% | 8.10 | 437 / 605 |
uterus | 100% | 1164.91 | 170 / 170 | 59% | 6.23 | 271 / 459 |
ovary | 100% | 963.71 | 180 / 180 | 58% | 5.01 | 248 / 430 |
pancreas | 73% | 388.80 | 238 / 328 | 83% | 8.52 | 147 / 178 |
bladder | 100% | 1422.24 | 21 / 21 | 51% | 5.11 | 259 / 504 |
stomach | 88% | 756.96 | 317 / 359 | 57% | 5.77 | 163 / 286 |
intestine | 85% | 854.44 | 819 / 966 | 50% | 4.60 | 262 / 527 |
adipose | 100% | 1219.89 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2074.32 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2046.34 | 801 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 94% | 28.29 | 75 / 80 |
heart | 88% | 1038.96 | 758 / 861 | 0% | 0 | 0 / 0 |
liver | 55% | 345.51 | 124 / 226 | 20% | 2.04 | 83 / 406 |
spleen | 64% | 291.62 | 154 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 53% | 6.55 | 24 / 45 |
lymph node | 0% | 0 | 0 / 0 | 21% | 1.32 | 6 / 29 |
peripheral blood | 8% | 36.52 | 70 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0046907 | Biological process | intracellular transport |
GO_0090141 | Biological process | positive regulation of mitochondrial fission |
GO_0045087 | Biological process | innate immune response |
GO_0030041 | Biological process | actin filament polymerization |
GO_0045010 | Biological process | actin nucleation |
GO_0048193 | Biological process | Golgi vesicle transport |
GO_0051639 | Biological process | actin filament network formation |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0016192 | Biological process | vesicle-mediated transport |
GO_0015031 | Biological process | protein transport |
GO_0051295 | Biological process | establishment of meiotic spindle localization |
GO_0036089 | Biological process | cleavage furrow formation |
GO_0070649 | Biological process | formin-nucleated actin cable assembly |
GO_2000781 | Biological process | positive regulation of double-strand break repair |
GO_0040038 | Biological process | polar body extrusion after meiotic divisions |
GO_0005856 | Cellular component | cytoskeleton |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005938 | Cellular component | cell cortex |
GO_0005741 | Cellular component | mitochondrial outer membrane |
GO_0032154 | Cellular component | cleavage furrow |
GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
GO_0008017 | Molecular function | microtubule binding |
GO_0005515 | Molecular function | protein binding |
GO_0003779 | Molecular function | actin binding |
Gene name | SPIRE1 |
Protein name | SPIRE1 protein Protein spire homolog 1 (Spir-1) Spire type actin nucleation factor 1 |
Synonyms | KIAA1135 SPIR1 |
Description | FUNCTION: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament . Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport . Required for asymmetric spindle positioning and asymmetric cell division during meiosis . Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis . Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage . In addition, promotes innate immune signaling downstream of dsRNA sensing . Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 . . |
Accessions | ENST00000309836.9 ENST00000449797.5 ENST00000410092.7 [Q08AE8-2] ENST00000497844.6 K7EMJ7 ENST00000453447.6 [Q08AE8-5] K7ENV1 J3KNG6 C9JYR7 ENST00000440472.6 [Q08AE8-4] K7EQR2 ENST00000462226.1 ENST00000592156.5 Q08AE8 ENST00000409402.9 [Q08AE8-1] Q96AS4 |