SPEF1 | OmnibusX

Name	Number of supported studies	Average coverage
ciliated cell	17 studies	42% ± 20%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPEF1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	90%	864.79	2390 / 2642	80%	8.82	562 / 705
kidney	96%	181.94	85 / 89	70%	5.70	634 / 901
thymus	96%	211.79	624 / 653	63%	3.26	383 / 605
ovary	37%	31.84	66 / 180	79%	8.88	339 / 430
lung	58%	322.16	336 / 578	27%	1.91	316 / 1155
breast	8%	6.20	35 / 459	62%	5.27	698 / 1118
uterus	43%	100.85	73 / 170	26%	2.65	120 / 459
pancreas	20%	15.27	64 / 328	16%	1.26	29 / 178
prostate	9%	7.62	22 / 245	17%	0.89	84 / 502
adrenal gland	9%	7.10	24 / 258	13%	0.43	29 / 230
esophagus	7%	6.01	106 / 1445	4%	0.14	7 / 183
skin	0%	0.22	6 / 1809	10%	0.39	49 / 472
intestine	7%	5.19	67 / 966	3%	0.29	18 / 527
bladder	0%	0	0 / 21	9%	0.37	45 / 504
liver	0%	0	0 / 226	7%	0.42	28 / 406
tonsil	0%	0	0 / 0	4%	0.15	2 / 45
eye	0%	0	0 / 0	4%	0.26	3 / 80
lymph node	0%	0	0 / 0	3%	0.10	1 / 29
stomach	1%	0.88	4 / 359	2%	0.12	5 / 286
adipose	1%	0.99	17 / 1204	0%	0	0 / 0
heart	1%	0.50	5 / 861	0%	0	0 / 0
peripheral blood	0%	1.77	3 / 929	0%	0	0 / 0
muscle	0%	0.17	2 / 803	0%	0	0 / 0
blood vessel	0%	0.06	1 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0030032	Biological process	lamellipodium assembly
GO_0051493	Biological process	regulation of cytoskeleton organization
GO_0007026	Biological process	negative regulation of microtubule depolymerization
GO_1904158	Biological process	axonemal central apparatus assembly
GO_2000095	Biological process	regulation of Wnt signaling pathway, planar cell polarity pathway
GO_0046847	Biological process	filopodium assembly
GO_0003341	Biological process	cilium movement
GO_0001578	Biological process	microtubule bundle formation
GO_0016477	Biological process	cell migration
GO_0005902	Cellular component	microvillus
GO_0016324	Cellular component	apical plasma membrane
GO_0097729	Cellular component	9+2 motile cilium
GO_0005874	Cellular component	microtubule
GO_0005930	Cellular component	axoneme
GO_1990716	Cellular component	axonemal central apparatus
GO_0097542	Cellular component	ciliary tip
GO_0030175	Cellular component	filopodium
GO_0001725	Cellular component	stress fiber
GO_0005737	Cellular component	cytoplasm
GO_0030027	Cellular component	lamellipodium
GO_0016323	Cellular component	basolateral plasma membrane
GO_0003779	Molecular function	actin binding
GO_0008017	Molecular function	microtubule binding
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

Gene name	SPEF1
Protein name	Sperm flagellar protein 1
Synonyms	C20orf28
Description	FUNCTION: Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (By similarity). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs . Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity). .
Accessions	Q9Y4P9 ENST00000379756.3 [Q9Y4P9-1]

SPEF1 report