SP7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SP7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SP7 at tissue level.

III. Associated gene sets

GO_0071344Biological processdiphosphate metabolic process
GO_0001649Biological processosteoblast differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032868Biological processresponse to insulin
GO_0014070Biological processresponse to organic cyclic compound
GO_0060218Biological processhematopoietic stem cell differentiation
GO_0071529Biological processcementum mineralization
GO_0010467Biological processgene expression
GO_2000738Biological processpositive regulation of stem cell differentiation
GO_0034224Biological processcellular response to zinc ion starvation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding
GO_0017151Molecular functionDEAD/H-box RNA helicase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSP7
Protein nameTranscription factor Sp7 (Zinc finger protein osterix)
Sp7 transcription factor
SynonymsOSX
DescriptionFUNCTION: Transcriptional activator essential for osteoblast differentiation . Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). .

AccessionsENST00000536324.4 [Q8TDD2-1]
ENST00000303846.3 [Q8TDD2-1]
ENST00000708983.1 [Q8TDD2-2]
F8VV67
ENST00000537210.2 [Q8TDD2-2]
Q8TDD2
ENST00000708981.1 [Q8TDD2-1]
ENST00000708982.1 [Q8TDD2-1]
ENST00000547755.1