SMARCD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002052Biological processpositive regulation of neuroblast proliferation
GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0042692Biological processmuscle cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0051152Biological processpositive regulation of smooth muscle cell differentiation
GO_0006338Biological processchromatin remodeling
GO_0070316Biological processregulation of G0 to G1 transition
GO_0045597Biological processpositive regulation of cell differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0003219Biological processcardiac right ventricle formation
GO_2000819Biological processregulation of nucleotide-excision repair
GO_0006337Biological processnucleosome disassembly
GO_0003139Biological processsecondary heart field specification
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0007399Biological processnervous system development
GO_0003407Biological processneural retina development
GO_0071565Cellular componentnBAF complex
GO_0071564Cellular componentnpBAF complex
GO_0016514Cellular componentSWI/SNF complex
GO_0005654Cellular componentnucleoplasm
GO_0035060Cellular componentbrahma complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0016922Molecular functionnuclear receptor binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003682Molecular functionchromatin binding
GO_0001221Molecular functiontranscription coregulator binding
GO_0005102Molecular functionsignaling receptor binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0003713Molecular functiontranscription coactivator activity

IV. Literature review

[source]
Gene nameSMARCD3
Protein nameSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (60 kDa BRG-1/Brm-associated factor subunit C) (BRG1-associated factor 60C) (BAF60C)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SynonymsBAF60C
tcag7.774
DescriptionFUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). .

AccessionsENST00000356800.6 [Q6STE5-2]
ENST00000392811.6 [Q6STE5-2]
F8WBJ3
ENST00000485592.5
ENST00000491651.1
Q6STE5
A0A090N8Z9
H7C4E9
ENST00000469154.5
C9JYI7
ENST00000262188.13 [Q6STE5-1]