SMARCA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0030182Biological processneuron differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0007420Biological processbrain development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0090537Cellular componentCERF complex
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_1904949Cellular componentATPase complex
GO_0016589Cellular componentNURF complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0004386Molecular functionhelicase activity
GO_0016787Molecular functionhydrolase activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0036310Molecular functionATP-dependent DNA/DNA annealing activity
GO_0005524Molecular functionATP binding
GO_0031491Molecular functionnucleosome binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMARCA1
Protein nameProbable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMARCA1 protein
SMARCA1 protein (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1)
SynonymsSNF2L1
SNF2L
hCG_1980650
DescriptionFUNCTION: [Isoform 1]: Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity . Acts as a negative regulator of chromatin remodelers by generating inactive complexes . .; FUNCTION: [Isoform 2]: Helicase that possesses intrinsic ATP-dependent chromatin-remodeling activity . ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate . Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair . Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template . Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes . The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template . The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template . Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity . Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development . May promote neurite outgrowth . May be involved in the development of luteal cells . .

AccessionsENST00000371121.5
A0A0A0MRP6
ENST00000371123.5
P28370
ENST00000371122.8 [P28370-1]
Q86UA8
B7ZLQ5