Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 23 studies | 44% ± 26% | |
astrocyte | 17 studies | 44% ± 23% | |
microglial cell | 16 studies | 67% ± 21% | |
oligodendrocyte | 15 studies | 54% ± 16% | |
oligodendrocyte precursor cell | 14 studies | 53% ± 19% | |
fibroblast | 13 studies | 35% ± 13% | |
endothelial cell | 11 studies | 30% ± 15% | |
myeloid cell | 8 studies | 45% ± 24% | |
GABAergic neuron | 7 studies | 46% ± 17% | |
endothelial cell of lymphatic vessel | 7 studies | 34% ± 13% | |
adipocyte | 6 studies | 28% ± 8% | |
dendritic cell | 6 studies | 37% ± 6% | |
glutamatergic neuron | 5 studies | 43% ± 23% | |
T cell | 5 studies | 26% ± 9% | |
pericyte | 5 studies | 28% ± 6% | |
CD4-positive, alpha-beta T cell | 3 studies | 28% ± 6% | |
CD8-positive, alpha-beta T cell | 3 studies | 23% ± 6% | |
mononuclear phagocyte | 3 studies | 37% ± 10% | |
regulatory T cell | 3 studies | 21% ± 6% | |
connective tissue cell | 3 studies | 17% ± 1% | |
B cell | 3 studies | 23% ± 9% | |
monocyte | 3 studies | 46% ± 12% | |
natural killer cell | 3 studies | 30% ± 5% | |
lymphocyte | 3 studies | 30% ± 6% | |
interneuron | 3 studies | 38% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 1190.15 | 244 / 245 | 98% | 20.76 | 493 / 502 |
brain | 92% | 910.35 | 2433 / 2642 | 100% | 27.60 | 705 / 705 |
lung | 100% | 1056.99 | 576 / 578 | 83% | 10.15 | 954 / 1155 |
breast | 99% | 880.42 | 455 / 459 | 75% | 5.40 | 839 / 1118 |
esophagus | 100% | 1361.37 | 1445 / 1445 | 67% | 8.75 | 122 / 183 |
skin | 99% | 1158.02 | 1795 / 1809 | 62% | 5.01 | 293 / 472 |
uterus | 100% | 777.22 | 170 / 170 | 61% | 7.03 | 280 / 459 |
kidney | 76% | 287.07 | 68 / 89 | 82% | 14.26 | 735 / 901 |
adrenal gland | 98% | 899.13 | 253 / 258 | 58% | 4.42 | 134 / 230 |
thymus | 98% | 704.76 | 640 / 653 | 58% | 7.13 | 349 / 605 |
bladder | 100% | 2035.71 | 21 / 21 | 51% | 4.42 | 255 / 504 |
ovary | 100% | 1021.59 | 180 / 180 | 45% | 2.53 | 194 / 430 |
stomach | 95% | 702.49 | 342 / 359 | 42% | 2.81 | 121 / 286 |
intestine | 100% | 1178.94 | 964 / 966 | 31% | 2.05 | 161 / 527 |
adipose | 100% | 1421.06 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 21.55 | 29 / 29 |
spleen | 100% | 1564.99 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 926.96 | 1323 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 14.93 | 41 / 45 |
peripheral blood | 88% | 413.66 | 817 / 929 | 0% | 0 | 0 / 0 |
heart | 81% | 480.36 | 696 / 861 | 0% | 0 | 0 / 0 |
pancreas | 13% | 34.84 | 42 / 328 | 68% | 5.71 | 121 / 178 |
liver | 44% | 134.08 | 99 / 226 | 29% | 1.99 | 116 / 406 |
muscle | 50% | 164.99 | 398 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 15% | 0.64 | 12 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0098719 | Biological process | sodium ion import across plasma membrane |
GO_0006811 | Biological process | monoatomic ion transport |
GO_0051453 | Biological process | regulation of intracellular pH |
GO_0090382 | Biological process | phagosome maturation |
GO_0071805 | Biological process | potassium ion transmembrane transport |
GO_1902600 | Biological process | proton transmembrane transport |
GO_0042742 | Biological process | defense response to bacterium |
GO_0031901 | Cellular component | early endosome membrane |
GO_0055038 | Cellular component | recycling endosome membrane |
GO_0031902 | Cellular component | late endosome membrane |
GO_0030670 | Cellular component | phagocytic vesicle membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0032009 | Cellular component | early phagosome |
GO_0055037 | Cellular component | recycling endosome |
GO_0005769 | Cellular component | early endosome |
GO_0015385 | Molecular function | sodium:proton antiporter activity |
GO_0015386 | Molecular function | potassium:proton antiporter activity |
GO_0005515 | Molecular function | protein binding |
Gene name | SLC9A9 |
Protein name | Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9) Alternative protein SLC9A9 Solute carrier family 9 member A9 |
Synonyms | Nbla00118 NHE9 |
Description | FUNCTION: Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters . Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain . Regulates synaptic transmission by regulating the luminal pH of axonal endosomes (By similarity). Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages (By similarity). Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH (By similarity). . |
Accessions | ENST00000316549.11 Q8IVB4 ENST00000474727.2 F8WF83 C9IZP1 L8EBG2 ENST00000474151.1 |