SLC9A9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098719Biological processsodium ion import across plasma membrane
GO_0006811Biological processmonoatomic ion transport
GO_0051453Biological processregulation of intracellular pH
GO_0090382Biological processphagosome maturation
GO_0071805Biological processpotassium ion transmembrane transport
GO_1902600Biological processproton transmembrane transport
GO_0042742Biological processdefense response to bacterium
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0031902Cellular componentlate endosome membrane
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0005886Cellular componentplasma membrane
GO_0032009Cellular componentearly phagosome
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0015385Molecular functionsodium:proton antiporter activity
GO_0015386Molecular functionpotassium:proton antiporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC9A9
Protein nameSodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9)
Alternative protein SLC9A9
Solute carrier family 9 member A9
SynonymsNbla00118
NHE9
DescriptionFUNCTION: Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters . Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain . Regulates synaptic transmission by regulating the luminal pH of axonal endosomes (By similarity). Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages (By similarity). Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH (By similarity). .

AccessionsENST00000316549.11
Q8IVB4
ENST00000474727.2
F8WF83
C9IZP1
L8EBG2
ENST00000474151.1