SLC6A3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLC6A3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC6A3 at tissue level.

III. Associated gene sets

GO_0010039Biological processresponse to iron ion
GO_0015844Biological processmonoamine transport
GO_0021984Biological processadenohypophysis development
GO_0042053Biological processregulation of dopamine metabolic process
GO_0090494Biological processdopamine uptake
GO_0051583Biological processdopamine uptake involved in synaptic transmission
GO_0007608Biological processsensory perception of smell
GO_0045471Biological processresponse to ethanol
GO_0042416Biological processdopamine biosynthetic process
GO_0015872Biological processdopamine transport
GO_0051591Biological processresponse to cAMP
GO_0042220Biological processresponse to cocaine
GO_0051620Biological processnorepinephrine uptake
GO_0035094Biological processresponse to nicotine
GO_0006836Biological processneurotransmitter transport
GO_0015874Biological processnorepinephrine transport
GO_0050890Biological processcognition
GO_0006865Biological processamino acid transport
GO_0007595Biological processlactation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0060134Biological processprepulse inhibition
GO_0007626Biological processlocomotory behavior
GO_0040018Biological processpositive regulation of multicellular organism growth
GO_0035725Biological processsodium ion transmembrane transport
GO_1990384Biological processhyaloid vascular plexus regression
GO_0042420Biological processdopamine catabolic process
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0043679Cellular componentaxon terminus
GO_0043025Cellular componentneuronal cell body
GO_0098691Cellular componentdopaminergic synapse
GO_0043005Cellular componentneuron projection
GO_0016600Cellular componentflotillin complex
GO_0032809Cellular componentneuronal cell body membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0009986Cellular componentcell surface
GO_0005737Cellular componentcytoplasm
GO_0045211Cellular componentpostsynaptic membrane
GO_0030424Cellular componentaxon
GO_0051721Molecular functionprotein phosphatase 2A binding
GO_1901363Molecular functionheterocyclic compound binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0005326Molecular functionneurotransmitter transmembrane transporter activity
GO_0005102Molecular functionsignaling receptor binding
GO_0005334Molecular functionnorepinephrine:sodium symporter activity
GO_0008504Molecular functionmonoamine transmembrane transporter activity
GO_0002020Molecular functionprotease binding
GO_0043176Molecular functionamine binding
GO_0046872Molecular functionmetal ion binding
GO_0035240Molecular functiondopamine binding
GO_0005330Molecular functiondopamine:sodium symporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC6A3
Protein nameSodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)
Dopamine transporter
SynonymsDAT1
DescriptionFUNCTION: Mediates sodium- and chloride-dependent transport of dopamine . Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). .

AccessionsQ01959
ENST00000270349.12
ENST00000621716.2
Q9Y610