SLC39A7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098773Biological processskin epidermis development
GO_0071577Biological processzinc ion transmembrane transport
GO_0006882Biological processintracellular zinc ion homeostasis
GO_0110075Biological processregulation of ferroptosis
GO_0030183Biological processB cell differentiation
GO_0005654Cellular componentnucleoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005385Molecular functionzinc ion transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC39A7
Protein nameZinc transporter SLC39A7 (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7)
Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)
SynonymsHKE4
RING5
DescriptionFUNCTION: Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels . Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation . Has an essential role in B cell development and is required for proper B cell receptor signaling . Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (By similarity). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (By similarity). Has a protective role against ER stress in different biological contexts . Mediates Zn(2+)-induced ferroptosis . .

AccessionsENST00000418477.6
ENST00000416369.6
ENST00000374675.7
ENST00000374677.8
A0A8V8TNV9
ENST00000425069.5
A0A8V8TM53
ENST00000414916.5
ENST00000698687.1
ENST00000443773.6
ENST00000698688.1
ENST00000414757.5
ENST00000441854.6
ENST00000383214.8
ENST00000698680.1
Q92504
A2AAT0
ENST00000429042.5
ENST00000423043.6
ENST00000444757.5
A0A8V8TM21
ENST00000383213.8
ENST00000456261.6
ENST00000441953.6
ENST00000431735.6
ENST00000454420.5