SLC39A6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046649Biological processlymphocyte activation
GO_0030003Biological processintracellular monoatomic cation homeostasis
GO_0071578Biological processzinc ion import across plasma membrane
GO_0001837Biological processepithelial to mesenchymal transition
GO_0015701Biological processbicarbonate transport
GO_0071577Biological processzinc ion transmembrane transport
GO_0006882Biological processintracellular zinc ion homeostasis
GO_0050852Biological processT cell receptor signaling pathway
GO_0016324Cellular componentapical plasma membrane
GO_0045121Cellular componentmembrane raft
GO_0009986Cellular componentcell surface
GO_0031258Cellular componentlamellipodium membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005886Cellular componentplasma membrane
GO_0005385Molecular functionzinc ion transmembrane transporter activity
GO_0140410Molecular functionmonoatomic cation:bicarbonate symporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC39A6
Protein nameZinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)
Zinc transporter ZIP6 (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6)
SynonymsLIV1
ZIP6
DescriptionFUNCTION: Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) . When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) . The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence . In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis . Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes . Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition . .

AccessionsENST00000269187.10 [Q13433-1]
ENST00000586829.1
Q13433
K7EQ91
ENST00000590986.5 [Q13433-1]
ENST00000440549.6 [Q13433-2]