Name | Number of supported studies | Average coverage | |
---|---|---|---|
plasmacytoid dendritic cell | 9 studies | 20% ± 4% | |
basal cell | 6 studies | 24% ± 8% | |
fibroblast | 6 studies | 23% ± 7% | |
neuron | 5 studies | 34% ± 12% | |
GABAergic neuron | 5 studies | 31% ± 9% | |
oligodendrocyte precursor cell | 5 studies | 26% ± 7% | |
epithelial cell | 4 studies | 38% ± 25% | |
club cell | 4 studies | 26% ± 7% | |
ciliated cell | 4 studies | 26% ± 9% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 71% ± 8% | |
luminal cell of prostate epithelium | 4 studies | 47% ± 6% | |
glutamatergic neuron | 4 studies | 35% ± 10% | |
interneuron | 4 studies | 29% ± 12% | |
connective tissue cell | 4 studies | 30% ± 11% | |
pericyte | 3 studies | 18% ± 3% | |
myofibroblast cell | 3 studies | 24% ± 10% | |
oligodendrocyte | 3 studies | 21% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 7044.86 | 245 / 245 | 100% | 449.42 | 500 / 502 |
breast | 100% | 6060.91 | 459 / 459 | 99% | 1337.02 | 1103 / 1118 |
brain | 100% | 2735.52 | 2630 / 2642 | 96% | 117.91 | 680 / 705 |
skin | 100% | 5972.17 | 1809 / 1809 | 95% | 205.93 | 450 / 472 |
uterus | 99% | 3183.78 | 169 / 170 | 82% | 85.75 | 377 / 459 |
lung | 99% | 1857.33 | 572 / 578 | 81% | 83.30 | 936 / 1155 |
thymus | 100% | 2270.07 | 652 / 653 | 80% | 73.67 | 484 / 605 |
adrenal gland | 100% | 2580.78 | 257 / 258 | 78% | 120.24 | 179 / 230 |
bladder | 100% | 4227.57 | 21 / 21 | 75% | 88.07 | 377 / 504 |
esophagus | 99% | 2041.15 | 1432 / 1445 | 68% | 86.94 | 125 / 183 |
kidney | 100% | 2184.46 | 89 / 89 | 67% | 56.01 | 606 / 901 |
pancreas | 99% | 1588.34 | 325 / 328 | 63% | 45.38 | 112 / 178 |
ovary | 100% | 4738.33 | 180 / 180 | 48% | 33.26 | 205 / 430 |
stomach | 100% | 1593.38 | 358 / 359 | 42% | 25.61 | 120 / 286 |
intestine | 98% | 1897.12 | 949 / 966 | 36% | 24.03 | 190 / 527 |
adipose | 100% | 2730.65 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3183.54 | 1331 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1375.32 | 240 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 90.82 | 42 / 45 |
muscle | 92% | 1034.76 | 742 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 89% | 122.41 | 71 / 80 |
heart | 85% | 1057.51 | 731 / 861 | 0% | 0 | 0 / 0 |
liver | 60% | 495.30 | 136 / 226 | 17% | 17.34 | 68 / 406 |
peripheral blood | 45% | 1116.05 | 418 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 31% | 19.47 | 9 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0046649 | Biological process | lymphocyte activation |
GO_0030003 | Biological process | intracellular monoatomic cation homeostasis |
GO_0071578 | Biological process | zinc ion import across plasma membrane |
GO_0001837 | Biological process | epithelial to mesenchymal transition |
GO_0015701 | Biological process | bicarbonate transport |
GO_0071577 | Biological process | zinc ion transmembrane transport |
GO_0006882 | Biological process | intracellular zinc ion homeostasis |
GO_0050852 | Biological process | T cell receptor signaling pathway |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0045121 | Cellular component | membrane raft |
GO_0009986 | Cellular component | cell surface |
GO_0031258 | Cellular component | lamellipodium membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005886 | Cellular component | plasma membrane |
GO_0005385 | Molecular function | zinc ion transmembrane transporter activity |
GO_0140410 | Molecular function | monoatomic cation:bicarbonate symporter activity |
GO_0005515 | Molecular function | protein binding |
Gene name | SLC39A6 |
Protein name | Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) Zinc transporter ZIP6 (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) |
Synonyms | LIV1 ZIP6 |
Description | FUNCTION: Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) . When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) . The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence . In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis . Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes . Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition . . |
Accessions | ENST00000269187.10 [Q13433-1] ENST00000586829.1 Q13433 K7EQ91 ENST00000590986.5 [Q13433-1] ENST00000440549.6 [Q13433-2] |