SLC27A5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008206Biological processbile acid metabolic process
GO_0006642Biological processtriglyceride mobilization
GO_0000038Biological processvery long-chain fatty acid metabolic process
GO_0051649Biological processestablishment of localization in cell
GO_0015911Biological processlong-chain fatty acid import across plasma membrane
GO_0015721Biological processbile acid and bile salt transport
GO_0044539Biological processlong-chain fatty acid import into cell
GO_0001676Biological processlong-chain fatty acid metabolic process
GO_0006699Biological processbile acid biosynthetic process
GO_0046951Biological processketone body biosynthetic process
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0032991Cellular componentprotein-containing complex
GO_0009925Cellular componentbasal plasma membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005324Molecular functionlong-chain fatty acid transmembrane transporter activity
GO_0015245Molecular functionfatty acid transmembrane transporter activity
GO_0031957Molecular functionvery long-chain fatty acid-CoA ligase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0004467Molecular functionlong-chain fatty acid-CoA ligase activity
GO_0047747Molecular functioncholate-CoA ligase activity
GO_0016491Molecular functionoxidoreductase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC27A5
Protein nameLong-chain fatty acid transport protein 5 (FATP-5) (Fatty acid transport protein 5) (Bile acid-CoA ligase) (BA-CoA ligase) (BAL) (Bile acyl-CoA synthetase) (BACS) (EC 6.2.1.7) (Cholate--CoA ligase) (Fatty-acid-coenzyme A ligase, very long-chain 3) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 5) (Very long-chain acyl-CoA synthetase homolog 2) (VLCS-H2) (VLCSH2) (EC 6.2.1.-) (Very long-chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR)
long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
SynonymsACSB
FATP5
ACSVL6
FACVL3
DescriptionFUNCTION: May mediate the import of long-chain fatty acids (LCFA) by facilitating their transport across cell membranes . Also catalyzes the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates . Mainly functions as a bile acyl-CoA synthetase catalyzing the activation of bile acids via ATP-dependent formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine . Both primary bile acids (cholic acid and chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates . In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate ((25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate or THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol . Plays an important role in hepatic fatty acid uptake and bile acid reconjugation and recycling but not in de novo synthesis of bile acids (By similarity). .

AccessionsQ9Y2P5
ENST00000601355.1 [Q9Y2P5-2]
ENST00000594786.1
ENST00000595851.5
M0R075
ENST00000263093.7 [Q9Y2P5-1]