| Name | cholate-CoA ligase activity |
| ID | GO_0047747 |
| collection_id | Molecular function |
| Alternative ID | GO:0047477 |
| Exact synonym | 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity |
| Description | Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. This reaction is the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates. |
| Related synonym | 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming), 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity, 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity, BAL activity, THCA-CoA ligase activity, bile acid CoA ligase activity, bile acid coenzyme A ligase activity, cholate thiokinase activity, cholate:CoA ligase (AMP-forming), cholic acid:CoA ligase activity, cholic thiokinase activity, choloyl coenzyme A synthetase activity, choloyl-CoA synthetase activity, cholyl-CoA synthetase activity, trihydroxycoprostanoyl-CoA synthetase activity |
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| Genes |