SLC27A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008206Biological processbile acid metabolic process
GO_0097089Biological processmethyl-branched fatty acid metabolic process
GO_0001561Biological processfatty acid alpha-oxidation
GO_0042760Biological processvery long-chain fatty acid catabolic process
GO_0044539Biological processlong-chain fatty acid import into cell
GO_0001676Biological processlong-chain fatty acid metabolic process
GO_0006699Biological processbile acid biosynthetic process
GO_0006635Biological processfatty acid beta-oxidation
GO_0046949Biological processfatty-acyl-CoA biosynthetic process
GO_0005778Cellular componentperoxisomal membrane
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070062Cellular componentextracellular exosome
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005829Cellular componentcytosol
GO_0019899Molecular functionenzyme binding
GO_0005324Molecular functionlong-chain fatty acid transmembrane transporter activity
GO_0015245Molecular functionfatty acid transmembrane transporter activity
GO_0031957Molecular functionvery long-chain fatty acid-CoA ligase activity
GO_0004467Molecular functionlong-chain fatty acid-CoA ligase activity
GO_0047747Molecular functioncholate-CoA ligase activity
GO_0070251Molecular functionpristanate-CoA ligase activity
GO_0047676Molecular functionarachidonate-CoA ligase activity
GO_0005524Molecular functionATP binding
GO_1901480Molecular functionoleate transmembrane transporter activity
GO_0050197Molecular functionphytanate-CoA ligase activity

IV. Literature review

[source]
Gene nameSLC27A2
Protein namelong-chain-fatty-acid--CoA ligase (EC 6.2.1.3) (Long-chain-fatty-acid--CoA ligase)
Long-chain fatty acid transport protein 2 (Arachidonate--CoA ligase) (EC 6.2.1.15) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Phytanate--CoA ligase) (EC 6.2.1.24) (Solute carrier family 27 member 2) (THCA-CoA ligase) (EC 6.2.1.7) (Very long-chain acyl-CoA synthetase) (VLACS) (VLCS) (EC 6.2.1.-) (Very long-chain-fatty-acid-CoA ligase)
SynonymsACSVL1
FATP2
VLACS
hCG_39815
FACVL1
DescriptionFUNCTION: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake . Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake . Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis . Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid . May contribute to the synthesis of sphingosine-1-phosphate . Does not activate C24 bile acids, cholate and chenodeoxycholate . In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol . However, it is not critical for THCA activation and bile synthesis in vivo . .; FUNCTION: [Isoform 1]: Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids . Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol . .; FUNCTION: [Isoform 2]: Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids. .

AccessionsENST00000380902.8 [O14975-2]
G3V1R7
ENST00000267842.10 [O14975-1]
O14975
ENST00000544960.1