SLC25A12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070778Biological processL-aspartate transmembrane transport
GO_0015813Biological processL-glutamate transmembrane transport
GO_0015810Biological processaspartate transmembrane transport
GO_0009066Biological processaspartate family amino acid metabolic process
GO_0015804Biological processneutral amino acid transport
GO_0006094Biological processgluconeogenesis
GO_0043490Biological processmalate-aspartate shuttle
GO_0051592Biological processresponse to calcium ion
GO_1902600Biological processproton transmembrane transport
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0015172Molecular functionacidic amino acid transmembrane transporter activity
GO_0015183Molecular functionL-aspartate transmembrane transporter activity
GO_0042802Molecular functionidentical protein binding
GO_0000514Molecular function3-sulfino-L-alanine: proton, glutamate antiporter activity
GO_0005313Molecular functionL-glutamate transmembrane transporter activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0000515Molecular functionaspartate:glutamate, proton antiporter activity

IV. Literature review

[source]
Gene nameSLC25A12
Protein nameElectrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Araceli hiperlarga) (Aralar) (Aralar1) (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12)
Solute carrier family 25 member 12
Solute carrier family 25 member 12 (cDNA FLJ57722, highly similar to Calcium-binding mitochondrial carrier protein Aralar1)
SynonymsAGC1
ARALAR1
DescriptionFUNCTION: Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle . Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation . .

AccessionsO75746
ENST00000426896.5
B4DGK6
ENST00000263812.8
ENST00000709717.1 [O75746-1]
F8W9J0
H0YFB2
ENST00000422440.7 [O75746-1]
ENST00000475360.6