SLC1A5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006868Biological processglutamine transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0070207Biological processprotein homotrimerization
GO_0030218Biological processerythrocyte differentiation
GO_0046718Biological processsymbiont entry into host cell
GO_0015804Biological processneutral amino acid transport
GO_0010585Biological processglutamine secretion
GO_0015825Biological processL-serine transport
GO_0006865Biological processamino acid transport
GO_1903803Biological processL-glutamine import across plasma membrane
GO_0140009Biological processL-aspartate import across plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0009925Cellular componentbasal plasma membrane
GO_0042470Cellular componentmelanosome
GO_0015171Molecular functionamino acid transmembrane transporter activity
GO_0038023Molecular functionsignaling receptor activity
GO_0015194Molecular functionL-serine transmembrane transporter activity
GO_0015183Molecular functionL-aspartate transmembrane transporter activity
GO_0015293Molecular functionsymporter activity
GO_0015186Molecular functionL-glutamine transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0001618Molecular functionvirus receptor activity
GO_0015175Molecular functionneutral L-amino acid transmembrane transporter activity
GO_0046872Molecular functionmetal ion binding
GO_0022834Molecular functionligand-gated channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC1A5
Protein nameSolute carrier family 1 member 5
Amino acid transporter
Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5)
SynonymsRDRC
ASCT2
RDR
M7V1
DescriptionFUNCTION: Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion . The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation . The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system . Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons . Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development . .; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. .; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. .; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. .

AccessionsQ15758
ENST00000434726.6 [Q15758-2]
M0R144
ENST00000593713.1
ENST00000594991.5
M0QXM4
ENST00000542575.6 [Q15758-1]
ENST00000598022.1
Q71UA6
ENST00000412532.6 [Q15758-3]
M0QX44