Name | Number of supported studies | Average coverage | |
---|---|---|---|
basal cell | 15 studies | 29% ± 10% | |
fibroblast | 14 studies | 27% ± 10% | |
plasmacytoid dendritic cell | 10 studies | 27% ± 8% | |
plasma cell | 7 studies | 24% ± 9% | |
conventional dendritic cell | 6 studies | 25% ± 6% | |
goblet cell | 6 studies | 29% ± 10% | |
mast cell | 5 studies | 20% ± 3% | |
epithelial cell | 5 studies | 27% ± 10% | |
non-classical monocyte | 4 studies | 25% ± 6% | |
endothelial cell | 4 studies | 25% ± 3% | |
erythrocyte | 4 studies | 33% ± 20% | |
endothelial cell of vascular tree | 4 studies | 21% ± 3% | |
natural killer cell | 4 studies | 20% ± 3% | |
secretory cell | 3 studies | 20% ± 3% | |
plasmablast | 3 studies | 34% ± 16% | |
extravillous trophoblast | 3 studies | 21% ± 2% | |
dendritic cell | 3 studies | 33% ± 8% | |
serous secreting cell | 3 studies | 19% ± 2% | |
macrophage | 3 studies | 21% ± 3% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 20% ± 3% | |
erythroblast | 3 studies | 38% ± 19% | |
CD8-positive, alpha-beta T cell | 3 studies | 24% ± 6% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
lung | 4 studies | 22% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 9148.27 | 245 / 245 | 100% | 260.14 | 500 / 502 |
bladder | 100% | 9947.43 | 21 / 21 | 99% | 241.30 | 498 / 504 |
esophagus | 99% | 4523.11 | 1425 / 1445 | 100% | 180.41 | 183 / 183 |
skin | 100% | 8471.46 | 1806 / 1809 | 98% | 142.92 | 463 / 472 |
breast | 100% | 7147.88 | 459 / 459 | 98% | 153.63 | 1094 / 1118 |
lung | 100% | 6144.21 | 578 / 578 | 98% | 183.30 | 1130 / 1155 |
uterus | 100% | 3628.55 | 170 / 170 | 97% | 244.73 | 447 / 459 |
stomach | 100% | 3537.56 | 359 / 359 | 97% | 195.49 | 278 / 286 |
ovary | 100% | 3999.42 | 180 / 180 | 96% | 103.10 | 414 / 430 |
intestine | 95% | 3088.90 | 914 / 966 | 98% | 228.38 | 518 / 527 |
kidney | 100% | 2975.80 | 89 / 89 | 80% | 55.66 | 717 / 901 |
pancreas | 77% | 1630.20 | 252 / 328 | 96% | 123.85 | 171 / 178 |
thymus | 72% | 1218.30 | 473 / 653 | 49% | 29.51 | 296 / 605 |
adipose | 100% | 6759.78 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 89.63 | 29 / 29 |
spleen | 100% | 3496.14 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 234.52 | 45 / 45 |
blood vessel | 97% | 3670.98 | 1290 / 1335 | 0% | 0 | 0 / 0 |
adrenal gland | 76% | 1164.10 | 196 / 258 | 14% | 9.26 | 32 / 230 |
peripheral blood | 88% | 3145.66 | 820 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 68% | 37.52 | 54 / 80 |
heart | 55% | 1001.44 | 474 / 861 | 0% | 0 | 0 / 0 |
liver | 6% | 89.28 | 13 / 226 | 26% | 21.82 | 105 / 406 |
brain | 5% | 64.23 | 123 / 2642 | 21% | 10.00 | 146 / 705 |
muscle | 9% | 110.55 | 69 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006868 | Biological process | glutamine transport |
GO_0150104 | Biological process | transport across blood-brain barrier |
GO_0070207 | Biological process | protein homotrimerization |
GO_0030218 | Biological process | erythrocyte differentiation |
GO_0046718 | Biological process | symbiont entry into host cell |
GO_0015804 | Biological process | neutral amino acid transport |
GO_0010585 | Biological process | glutamine secretion |
GO_0015825 | Biological process | L-serine transport |
GO_0006865 | Biological process | amino acid transport |
GO_1903803 | Biological process | L-glutamine import across plasma membrane |
GO_0140009 | Biological process | L-aspartate import across plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0009925 | Cellular component | basal plasma membrane |
GO_0042470 | Cellular component | melanosome |
GO_0015171 | Molecular function | amino acid transmembrane transporter activity |
GO_0038023 | Molecular function | signaling receptor activity |
GO_0015194 | Molecular function | L-serine transmembrane transporter activity |
GO_0015183 | Molecular function | L-aspartate transmembrane transporter activity |
GO_0015293 | Molecular function | symporter activity |
GO_0015186 | Molecular function | L-glutamine transmembrane transporter activity |
GO_0015297 | Molecular function | antiporter activity |
GO_0001618 | Molecular function | virus receptor activity |
GO_0015175 | Molecular function | neutral L-amino acid transmembrane transporter activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0022834 | Molecular function | ligand-gated channel activity |
GO_0005515 | Molecular function | protein binding |
Gene name | SLC1A5 |
Protein name | Solute carrier family 1 member 5 Amino acid transporter Neutral amino acid transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid transporter type 2) (Solute carrier family 1 member 5) |
Synonyms | RDRC ASCT2 RDR M7V1 |
Description | FUNCTION: Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion . The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation . The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system . Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons . Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development . .; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. .; FUNCTION: (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. .; FUNCTION: (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. . |
Accessions | Q15758 ENST00000434726.6 [Q15758-2] M0R144 ENST00000593713.1 ENST00000594991.5 M0QXM4 ENST00000542575.6 [Q15758-1] ENST00000598022.1 Q71UA6 ENST00000412532.6 [Q15758-3] M0QX44 |