SIX5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SIX5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIX5 at tissue level.

III. Associated gene sets

GO_0002088Biological processlens development in camera-type eye
GO_0160024Biological processLeydig cell proliferation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0007286Biological processspermatid development
GO_1902723Biological processnegative regulation of skeletal muscle satellite cell proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005794Cellular componentGolgi apparatus
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSIX5
Protein nameHomeobox protein SIX5 (DM locus-associated homeodomain protein) (Sine oculis homeobox homolog 5)
SIX homeobox 5
SynonymsDMAHP
DescriptionFUNCTION: Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). .

AccessionsH0YLF6
ENST00000560168.1
ENST00000560160.1
H0YLK1
ENST00000317578.7
Q8N196