SIX2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SIX2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIX2 at tissue level.

III. Associated gene sets

GO_0009948Biological processanterior/posterior axis specification
GO_0008283Biological processcell population proliferation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0097168Biological processmesenchymal stem cell proliferation
GO_0002062Biological processchondrocyte differentiation
GO_0090189Biological processregulation of branching involved in ureteric bud morphogenesis
GO_0001822Biological processkidney development
GO_0072137Biological processcondensed mesenchymal cell proliferation
GO_0030857Biological processnegative regulation of epithelial cell differentiation
GO_0072038Biological processmesenchymal stem cell maintenance involved in nephron morphogenesis
GO_1902732Biological processpositive regulation of chondrocyte proliferation
GO_0048557Biological processembryonic digestive tract morphogenesis
GO_0072028Biological processnephron morphogenesis
GO_0072006Biological processnephron development
GO_0072161Biological processmesenchymal cell differentiation involved in kidney development
GO_0006606Biological processprotein import into nucleus
GO_0009653Biological processanatomical structure morphogenesis
GO_0048701Biological processembryonic cranial skeleton morphogenesis
GO_0007501Biological processmesodermal cell fate specification
GO_0042474Biological processmiddle ear morphogenesis
GO_0030278Biological processregulation of ossification
GO_0032330Biological processregulation of chondrocyte differentiation
GO_0016477Biological processcell migration
GO_0003337Biological processmesenchymal to epithelial transition involved in metanephros morphogenesis
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0044877Molecular functionprotein-containing complex binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSIX2
Protein nameSIX homeobox 2
Homeobox protein SIX2 (Sine oculis homeobox homolog 2)
Synonyms
DescriptionFUNCTION: Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. May also be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration. .

AccessionsQ8TBA2
ENST00000303077.7
Q9NPC8