SIK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035556Biological processintracellular signal transduction
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0046626Biological processregulation of insulin receptor signaling pathway
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005524Molecular functionATP binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameSIK2
Protein nameSerine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)
SynonymsSNF1LK2
QIK
KIAA0781
DescriptionFUNCTION: Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism . Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators . Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity . In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL . Also plays a role in thymic T-cell development (By similarity). .

AccessionsQ9H0K1
ENST00000304987.4