Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 19 studies | 42% ± 14% | |
| astrocyte | 18 studies | 41% ± 17% | |
| oligodendrocyte | 14 studies | 40% ± 15% | |
| fibroblast | 12 studies | 34% ± 13% | |
| microglial cell | 11 studies | 30% ± 10% | |
| GABAergic neuron | 10 studies | 41% ± 21% | |
| pericyte | 10 studies | 33% ± 12% | |
| glutamatergic neuron | 10 studies | 46% ± 23% | |
| oligodendrocyte precursor cell | 10 studies | 34% ± 13% | |
| adipocyte | 10 studies | 76% ± 13% | |
| macrophage | 9 studies | 28% ± 9% | |
| smooth muscle cell | 8 studies | 29% ± 9% | |
| neuron | 7 studies | 34% ± 18% | |
| epithelial cell | 6 studies | 35% ± 16% | |
| retinal cone cell | 6 studies | 44% ± 22% | |
| endothelial cell of lymphatic vessel | 6 studies | 34% ± 11% | |
| cardiac muscle cell | 5 studies | 36% ± 11% | |
| ciliated cell | 5 studies | 30% ± 7% | |
| type I pneumocyte | 5 studies | 47% ± 12% | |
| type II pneumocyte | 5 studies | 30% ± 9% | |
| interneuron | 5 studies | 48% ± 24% | |
| hepatocyte | 4 studies | 60% ± 28% | |
| dendritic cell | 4 studies | 19% ± 4% | |
| retinal rod cell | 4 studies | 62% ± 4% | |
| monocyte | 4 studies | 33% ± 14% | |
| club cell | 4 studies | 28% ± 9% | |
| GABAergic interneuron | 3 studies | 32% ± 5% | |
| mesothelial cell | 3 studies | 31% ± 9% | |
| Mueller cell | 3 studies | 43% ± 15% | |
| amacrine cell | 3 studies | 29% ± 9% | |
| myeloid cell | 3 studies | 22% ± 3% | |
| endothelial cell of vascular tree | 3 studies | 33% ± 11% | |
| retinal pigment epithelial cell | 3 studies | 33% ± 21% | |
| ependymal cell | 3 studies | 52% ± 13% | |
| alveolar macrophage | 3 studies | 41% ± 10% | |
| capillary endothelial cell | 3 studies | 29% ± 7% | |
| myofibroblast cell | 3 studies | 25% ± 9% | |
| muscle cell | 3 studies | 35% ± 17% | |
| basal cell | 3 studies | 37% ± 20% | |
| granule cell | 3 studies | 27% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3144.76 | 1443 / 1445 | 100% | 21.03 | 183 / 183 |
| intestine | 100% | 3634.90 | 966 / 966 | 100% | 17.85 | 526 / 527 |
| lung | 100% | 5736.47 | 578 / 578 | 100% | 18.48 | 1151 / 1155 |
| stomach | 100% | 6462.26 | 359 / 359 | 100% | 20.26 | 285 / 286 |
| prostate | 100% | 3471.29 | 244 / 245 | 100% | 21.91 | 502 / 502 |
| kidney | 100% | 4035.93 | 89 / 89 | 100% | 29.71 | 897 / 901 |
| liver | 100% | 5532.23 | 226 / 226 | 100% | 28.15 | 404 / 406 |
| thymus | 100% | 3934.87 | 652 / 653 | 100% | 20.33 | 602 / 605 |
| brain | 99% | 3806.43 | 2618 / 2642 | 100% | 26.77 | 705 / 705 |
| pancreas | 99% | 3305.08 | 325 / 328 | 100% | 20.58 | 178 / 178 |
| ovary | 100% | 6877.30 | 180 / 180 | 99% | 17.11 | 426 / 430 |
| breast | 100% | 10068.84 | 459 / 459 | 98% | 17.03 | 1094 / 1118 |
| uterus | 100% | 3789.02 | 170 / 170 | 98% | 13.68 | 448 / 459 |
| skin | 100% | 3916.57 | 1809 / 1809 | 97% | 16.54 | 460 / 472 |
| bladder | 100% | 3704.62 | 21 / 21 | 96% | 12.72 | 484 / 504 |
| adrenal gland | 100% | 4246.37 | 258 / 258 | 94% | 27.72 | 217 / 230 |
| adipose | 100% | 12628.31 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 24.82 | 80 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.32 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 5.28 | 1 / 1 |
| blood vessel | 100% | 3770.66 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 8999.09 | 802 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2240.83 | 240 / 241 | 0% | 0 | 0 / 0 |
| heart | 94% | 3540.52 | 812 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 8.96 | 27 / 29 |
| peripheral blood | 34% | 765.08 | 319 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0046626 | Biological process | regulation of insulin receptor signaling pathway |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005524 | Molecular function | ATP binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0000287 | Molecular function | magnesium ion binding |
| Gene name | SIK2 |
| Protein name | Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2) |
| Synonyms | SNF1LK2 QIK KIAA0781 |
| Description | FUNCTION: Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism . Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators . Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity . In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL . Also plays a role in thymic T-cell development (By similarity). . |
| Accessions | Q9H0K1 ENST00000304987.4 |