SETD1A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SETD1A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SETD1A at tissue level.

III. Associated gene sets

GO_0032259Biological processmethylation
GO_1902275Biological processregulation of chromatin organization
GO_0006974Biological processDNA damage response
GO_0006338Biological processchromatin remodeling
GO_1902036Biological processregulation of hematopoietic stem cell differentiation
GO_0007420Biological processbrain development
GO_0035097Cellular componenthistone methyltransferase complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0048188Cellular componentSet1C/COMPASS complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042800Molecular functionhistone H3K4 methyltransferase activity
GO_0008013Molecular functionbeta-catenin binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003723Molecular functionRNA binding
GO_0140999Molecular functionhistone H3K4 trimethyltransferase activity
GO_0140945Molecular functionhistone H3K4 monomethyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSETD1A
Protein nameSET domain containing 1A, histone lysine methyltransferase
Alternative protein SETD1A
Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)
SynonymsKMT2F
KIAA0339
SET1
SET1A
DescriptionFUNCTION: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism . Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place . Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (By similarity) . Required for H3K4me1 mark at stalled replication forks. Mediates FANCD2-dependent nucleosome remodeling and RAD51 nucleofilaments stabilization at reversed forks, protecting them from nucleolytic degradation . Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated . Binds RNAs involved in RNA processing and the DNA damage response . .

AccessionsC9J2Z9
ENST00000452917.3
ENST00000684162.1
ENST00000262519.14
O15047
ENST00000710314.1
L0R6N9