SERTAD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030308Biological processnegative regulation of cell growth
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0140110Molecular functiontranscription regulator activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSERTAD2
Protein nameSERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2)
SynonymsTRIPBR2
KIAA0127
DescriptionFUNCTION: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. .

AccessionsQ14140
ENST00000313349.3