SCRIB report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SCRIB at tissue level.

III. Associated gene sets

GO_0043615Biological processastrocyte cell migration
GO_0009790Biological processembryo development
GO_0001921Biological processpositive regulation of receptor recycling
GO_0021747Biological processcochlear nucleus development
GO_0016080Biological processsynaptic vesicle targeting
GO_0008283Biological processcell population proliferation
GO_0090630Biological processactivation of GTPase activity
GO_0050918Biological processpositive chemotaxis
GO_0048488Biological processsynaptic vesicle endocytosis
GO_0060088Biological processauditory receptor cell stereocilium organization
GO_0060603Biological processmammary gland duct morphogenesis
GO_0043113Biological processreceptor clustering
GO_0042060Biological processwound healing
GO_0071896Biological processprotein localization to adherens junction
GO_0035089Biological processestablishment of apical/basal cell polarity
GO_0045197Biological processestablishment or maintenance of epithelial cell apical/basal polarity
GO_0001768Biological processestablishment of T cell polarity
GO_0060561Biological processapoptotic process involved in morphogenesis
GO_0098887Biological processneurotransmitter receptor transport, endosome to postsynaptic membrane
GO_0036342Biological processpost-anal tail morphogenesis
GO_0046007Biological processnegative regulation of activated T cell proliferation
GO_0045947Biological processnegative regulation of translational initiation
GO_0099149Biological processregulation of postsynaptic neurotransmitter receptor internalization
GO_0001843Biological processneural tube closure
GO_0032729Biological processpositive regulation of type II interferon production
GO_0045930Biological processnegative regulation of mitotic cell cycle
GO_0098609Biological processcell-cell adhesion
GO_0043065Biological processpositive regulation of apoptotic process
GO_0098968Biological processneurotransmitter receptor transport postsynaptic membrane to endosome
GO_0016477Biological processcell migration
GO_0030859Biological processpolarized epithelial cell differentiation
GO_0001772Cellular componentimmunological synapse
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0044291Cellular componentcell-cell contact zone
GO_0042734Cellular componentpresynaptic membrane
GO_0031252Cellular componentcell leading edge
GO_0005911Cellular componentcell-cell junction
GO_0099147Cellular componentextrinsic component of postsynaptic density membrane
GO_0034750Cellular componentScrib-APC-beta-catenin complex
GO_0005912Cellular componentadherens junction
GO_0035748Cellular componentmyelin sheath abaxonal region
GO_0014069Cellular componentpostsynaptic density
GO_0045211Cellular componentpostsynaptic membrane
GO_0030054Cellular componentcell junction
GO_0030027Cellular componentlamellipodium
GO_0016323Cellular componentbasolateral plasma membrane
GO_0045296Molecular functioncadherin binding
GO_0019901Molecular functionprotein kinase binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSCRIB
Protein nameProtein scribble homolog (Scribble) (hScrib) (Protein LAP4)
SCRIB overlapping open reading frame protein (oSCRIB)
SCRIB overlapping open reading frame protein (Scribble planar cell polarity protein)
SCRIB protein
Scribble planar cell polarity protein
Protein scribble homolog
SynonymsVARTUL
KIAA0147
SCRB1
CRIB1
LAP4
DescriptionFUNCTION: Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization . Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Most probably functions in the establishment of apico-basal cell polarity . May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium . May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling . May play a role in exocytosis and in the targeting of synaptic vesicles to synapses . Functions as an activator of Rac GTPase activity. .

FUNCTION: Represses translation of the downstream SCRIB protein . Translation of oSCRIB hinders SCRIB translation but does not completely abolish it, probably due to leaky scanning which allows the ribosome to bypass the weaker oSCRIB start codon and initiate translation at the stronger SCRIB start codon . .

AccessionsENST00000531942.1
A0A669KB89
ENST00000356994.7 [Q14160-3]
ENST00000674084.1
ENST00000674065.1
A0A669KAX5
Q14160
ENST00000622455
ENST00000633098.1
A0A0G2JMS7
ENST00000634208.1
ENST00000611528.2 [Q14160-2]
A0PJK8
ENST00000611528
A0A0G2JNZ2
ENST00000377533.7 [Q14160-2]
C0HLS1
ENST00000622455.4 [Q14160-1]
ENST00000526832.5
ENST00000612204.4 [Q14160-3]
H0YDF9
ENST00000320476.7 [Q14160-1]
H0YCG0
ENST00000612204
A0A0G2JPP5