SCN5A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0086012Biological processmembrane depolarization during cardiac muscle cell action potential
GO_0060372Biological processregulation of atrial cardiac muscle cell membrane repolarization
GO_0086067Biological processAV node cell to bundle of His cell communication
GO_0003161Biological processcardiac conduction system development
GO_0060307Biological processregulation of ventricular cardiac muscle cell membrane repolarization
GO_0086015Biological processSA node cell action potential
GO_0051899Biological processmembrane depolarization
GO_0086002Biological processcardiac muscle cell action potential involved in contraction
GO_0086047Biological processmembrane depolarization during Purkinje myocyte cell action potential
GO_0098912Biological processmembrane depolarization during atrial cardiac muscle cell action potential
GO_0086004Biological processregulation of cardiac muscle cell contraction
GO_0086016Biological processAV node cell action potential
GO_0014894Biological processresponse to denervation involved in regulation of muscle adaptation
GO_0086005Biological processventricular cardiac muscle cell action potential
GO_0002027Biological processregulation of heart rate
GO_0060373Biological processregulation of ventricular cardiac muscle cell membrane depolarization
GO_0086014Biological processatrial cardiac muscle cell action potential
GO_0060048Biological processcardiac muscle contraction
GO_0035725Biological processsodium ion transmembrane transport
GO_0071277Biological processcellular response to calcium ion
GO_0003231Biological processcardiac ventricle development
GO_0086046Biological processmembrane depolarization during SA node cell action potential
GO_0045760Biological processpositive regulation of action potential
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0086043Biological processbundle of His cell action potential
GO_0010765Biological processpositive regulation of sodium ion transport
GO_0006814Biological processsodium ion transport
GO_0060371Biological processregulation of atrial cardiac muscle cell membrane depolarization
GO_0003360Biological processbrainstem development
GO_0086045Biological processmembrane depolarization during AV node cell action potential
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0021549Biological processcerebellum development
GO_0086048Biological processmembrane depolarization during bundle of His cell action potential
GO_0086010Biological processmembrane depolarization during action potential
GO_1902305Biological processregulation of sodium ion transmembrane transport
GO_0021537Biological processtelencephalon development
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0030018Cellular componentZ disc
GO_0042383Cellular componentsarcolemma
GO_0005654Cellular componentnucleoplasm
GO_0009986Cellular componentcell surface
GO_0030315Cellular componentT-tubule
GO_0005783Cellular componentendoplasmic reticulum
GO_0016328Cellular componentlateral plasma membrane
GO_0001518Cellular componentvoltage-gated sodium channel complex
GO_0005901Cellular componentcaveola
GO_0014704Cellular componentintercalated disc
GO_0086006Molecular functionvoltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO_0019899Molecular functionenzyme binding
GO_0019904Molecular functionprotein domain specific binding
GO_0005248Molecular functionvoltage-gated sodium channel activity
GO_0050998Molecular functionnitric-oxide synthase binding
GO_0019901Molecular functionprotein kinase binding
GO_0086060Molecular functionvoltage-gated sodium channel activity involved in AV node cell action potential
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0097110Molecular functionscaffold protein binding
GO_0086062Molecular functionvoltage-gated sodium channel activity involved in Purkinje myocyte action potential
GO_0044325Molecular functiontransmembrane transporter binding
GO_0030506Molecular functionankyrin binding
GO_0086063Molecular functionvoltage-gated sodium channel activity involved in SA node cell action potential
GO_0086061Molecular functionvoltage-gated sodium channel activity involved in bundle of His cell action potential
GO_0005516Molecular functioncalmodulin binding
GO_0017134Molecular functionfibroblast growth factor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSCN5A
Protein nameSCN5A protein
Sodium channel protein
Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1)
Cardiac sodium channel alpha subunit (Sodium voltage-gated channel alpha subunit 5)
Nav1.5
Sodium voltage-gated channel alpha subunit 5
Voltage-gated sodium channel type V alpha
Cardiac sodium channel alpha subunit variant
Sodium channel type V alpha subunit
Synonyms
DescriptionFUNCTION: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient . It is a tetrodotoxin-resistant Na(+) channel isoform . This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels . .

FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .

FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .

FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .

FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .

FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .

FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .

AccessionsENST00000327956.6
Q8WWN6
Q2QFB5
A3EY19
E9PG18
ENST00000455624.6
ENST00000327956.7 [Q14524-2]
ENST00000449557.6
A3EY20
Q8WTS0
A0A0A0MT39
Q8WWN5
S5NU80
ENST00000414099.6
H9KVD2
Q8WTQ6
Q86V90
D3YHE8
Q14524
ENST00000413689.6
K4DIA1
ENST00000450102.6
A0A7R6M6R3
ENST00000333535.9 [Q14524-1]
A3EY21
E9PHB6
A0A7R6M6R4
ENST00000423572.7 [Q14524-2]
A3EY18