SCN11A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SCN11A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SCN11A at tissue level.

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0061367Biological processbehavioral response to acetic acid induced pain
GO_0001966Biological processthigmotaxis
GO_0048870Biological processcell motility
GO_0002544Biological processchronic inflammatory response
GO_0010996Biological processresponse to auditory stimulus
GO_0009408Biological processresponse to heat
GO_0009644Biological processresponse to high light intensity
GO_0086002Biological processcardiac muscle cell action potential involved in contraction
GO_0060073Biological processmicturition
GO_1990408Biological processcalcitonin gene-related peptide receptor signaling pathway
GO_1990770Biological processsmall intestine smooth muscle contraction
GO_0050966Biological processdetection of mechanical stimulus involved in sensory perception of pain
GO_0099610Biological processaction potential initiation
GO_0061368Biological processbehavioral response to formalin induced pain
GO_0010737Biological processprotein kinase A signaling
GO_0002526Biological processacute inflammatory response
GO_0007623Biological processcircadian rhythm
GO_0070417Biological processcellular response to cold
GO_0007409Biological processaxonogenesis
GO_0043303Biological processmast cell degranulation
GO_0060004Biological processreflex
GO_0050965Biological processdetection of temperature stimulus involved in sensory perception of pain
GO_0019228Biological processneuronal action potential
GO_0034695Biological processresponse to prostaglandin E
GO_0071731Biological processresponse to nitric oxide
GO_0060840Biological processartery development
GO_0086010Biological processmembrane depolarization during action potential
GO_0060538Biological processskeletal muscle organ development
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0009636Biological processresponse to toxic substance
GO_0160025Biological processsensory perception of itch
GO_0040040Biological processthermosensory behavior
GO_0035725Biological processsodium ion transmembrane transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0043025Cellular componentneuronal cell body
GO_0044299Cellular componentC-fiber
GO_0044295Cellular componentaxonal growth cone
GO_0001518Cellular componentvoltage-gated sodium channel complex
GO_0030424Cellular componentaxon
GO_0005248Molecular functionvoltage-gated sodium channel activity

IV. Literature review

[source]
Gene nameSCN11A
Protein nameSodium voltage-gated channel alpha subunit 11
Sodium channel protein
Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN)
Voltage-gated sodium channel NaN
SynonymsSNS2
SCN12A
DescriptionFUNCTION: Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient . Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system . Also involved in rapid BDNF-evoked neuronal depolarization . .

FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .

FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .

AccessionsENST00000302328.9 [Q9UI33-1]
ENST00000675672.1
ENST00000676045.1
ENST00000675223.1
ENST00000668754.1 [Q9UI33-1]
ENST00000675892.1
A0A6Q8PGY3
ENST00000676176.1
A0A6Q8PFM8
Q9UKU5
ENST00000456224.7 [Q9UI33-3]
A0A6Q8PGY6
A0A6Q8PGN4
Q9UI33
ENST00000444237.2 [Q9UI33-2]
A0A6Q8PF78