Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 25% ± 9% | |
B cell | 9 studies | 18% ± 2% | |
naive B cell | 6 studies | 19% ± 3% | |
microglial cell | 5 studies | 25% ± 6% | |
epithelial cell | 5 studies | 30% ± 10% | |
astrocyte | 5 studies | 27% ± 8% | |
natural killer cell | 5 studies | 18% ± 2% | |
macrophage | 5 studies | 24% ± 6% | |
oligodendrocyte precursor cell | 4 studies | 27% ± 9% | |
endothelial cell of lymphatic vessel | 4 studies | 20% ± 4% | |
oligodendrocyte | 4 studies | 25% ± 5% | |
plasmacytoid dendritic cell | 4 studies | 19% ± 1% | |
memory B cell | 4 studies | 17% ± 2% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 17% ± 1% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 19% ± 3% | |
non-classical monocyte | 3 studies | 25% ± 5% | |
precursor B cell | 3 studies | 19% ± 0% | |
immature B cell | 3 studies | 20% ± 0% | |
GABAergic neuron | 3 studies | 43% ± 3% | |
glutamatergic neuron | 3 studies | 52% ± 5% | |
abnormal cell | 3 studies | 26% ± 8% | |
fibroblast | 3 studies | 19% ± 4% | |
transit amplifying cell | 3 studies | 29% ± 18% | |
neuron | 3 studies | 23% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2855.61 | 1445 / 1445 | 100% | 33.16 | 183 / 183 |
intestine | 100% | 3204.07 | 966 / 966 | 100% | 28.28 | 527 / 527 |
prostate | 100% | 2923.89 | 245 / 245 | 100% | 22.74 | 502 / 502 |
skin | 100% | 3833.76 | 1809 / 1809 | 100% | 30.04 | 472 / 472 |
stomach | 100% | 2329.74 | 359 / 359 | 100% | 28.50 | 286 / 286 |
bladder | 100% | 2963.10 | 21 / 21 | 100% | 26.38 | 503 / 504 |
uterus | 100% | 3588.98 | 170 / 170 | 100% | 28.61 | 458 / 459 |
ovary | 100% | 3529.14 | 180 / 180 | 100% | 25.46 | 429 / 430 |
thymus | 100% | 2814.56 | 653 / 653 | 100% | 21.08 | 603 / 605 |
breast | 100% | 3183.58 | 459 / 459 | 100% | 29.81 | 1113 / 1118 |
lung | 100% | 3397.62 | 578 / 578 | 99% | 24.72 | 1147 / 1155 |
pancreas | 100% | 1447.71 | 327 / 328 | 99% | 20.55 | 177 / 178 |
kidney | 100% | 1908.43 | 89 / 89 | 99% | 17.33 | 888 / 901 |
brain | 98% | 1630.46 | 2601 / 2642 | 100% | 25.18 | 704 / 705 |
liver | 100% | 1940.43 | 226 / 226 | 98% | 13.40 | 398 / 406 |
adrenal gland | 100% | 2189.17 | 258 / 258 | 97% | 15.45 | 223 / 230 |
adipose | 100% | 3194.79 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2859.84 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 26.18 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 34.85 | 29 / 29 |
muscle | 100% | 2199.57 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3547.99 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 28.89 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.32 | 1 / 1 |
heart | 99% | 1593.71 | 849 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 96% | 2182.37 | 891 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_2000805 | Biological process | negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005634 | Cellular component | nucleus |
GO_1990269 | Molecular function | RNA polymerase II C-terminal domain phosphoserine binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | SCAF4 |
Protein name | SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15) |
Synonyms | KIAA1172 SFRS15 |
Description | FUNCTION: Anti-terminator protein required to prevent early mRNA termination during transcription . Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins . Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation . Independently of SCAF8, also acts as a suppressor of transcriptional readthrough . . |
Accessions | ENST00000286835.12 [O95104-1] ENST00000434667.3 [O95104-3] O95104 ENST00000399804.5 [O95104-2] |