SCAF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000805Biological processnegative regulation of termination of RNA polymerase II transcription, poly(A)-coupled
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_1990269Molecular functionRNA polymerase II C-terminal domain phosphoserine binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSCAF4
Protein nameSR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15)
SynonymsKIAA1172
SFRS15
DescriptionFUNCTION: Anti-terminator protein required to prevent early mRNA termination during transcription . Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins . Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation . Independently of SCAF8, also acts as a suppressor of transcriptional readthrough . .

AccessionsENST00000286835.12 [O95104-1]
ENST00000434667.3 [O95104-3]
O95104
ENST00000399804.5 [O95104-2]