SAE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0016925Biological processprotein sumoylation
GO_0033235Biological processpositive regulation of protein sumoylation
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0031510Cellular componentSUMO activating enzyme complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0046982Molecular functionprotein heterodimerization activity
GO_0008047Molecular functionenzyme activator activity
GO_0043008Molecular functionATP-dependent protein binding
GO_0004839Molecular functionubiquitin activating enzyme activity
GO_0019948Molecular functionSUMO activating enzyme activity
GO_0044388Molecular functionsmall protein activating enzyme binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSAE1
Protein nameSUMO-1 activating enzyme subunit 1, isoform CRA_a (SUMO1 activating enzyme subunit 1) (cDNA FLJ14689 fis, clone NT2RP2005204, highly similar to Ubiquitin-like 1-activating enzyme E1A)
SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]
SUMO1 activating enzyme subunit 1
SynonymsUBLE1A
SUA1
hCG_20373
AOS1
DescriptionFUNCTION: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. .

AccessionsENST00000600706.5
ENST00000659110.1
ENST00000594144.5
Q9UBE0
B3KNJ4
M0R286
ENST00000594526.5
M0QYM8
ENST00000664120.1
ENST00000413379.7 [Q9UBE0-3]
M0R054
M0QYP2
ENST00000414294.6
ENST00000392776.3 [Q9UBE0-2]
A0A590UKC5
ENST00000660039.1
M0QZS6
M0R375
ENST00000270225.12 [Q9UBE0-1]
ENST00000596995.1
A0A590UK93
A0A590UKA0
ENST00000598840.5
M0QX65
ENST00000600753.1
ENST00000597808.5