Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 12 studies | 23% ± 7% | |
CD8-positive, alpha-beta T cell | 8 studies | 24% ± 6% | |
CD4-positive, alpha-beta T cell | 7 studies | 29% ± 10% | |
epithelial cell | 6 studies | 28% ± 10% | |
natural killer cell | 6 studies | 28% ± 8% | |
myofibroblast cell | 5 studies | 18% ± 3% | |
pericyte | 5 studies | 17% ± 3% | |
regulatory T cell | 5 studies | 21% ± 4% | |
astrocyte | 5 studies | 23% ± 7% | |
T cell | 5 studies | 22% ± 4% | |
B cell | 4 studies | 19% ± 5% | |
hematopoietic precursor cell | 4 studies | 24% ± 4% | |
connective tissue cell | 4 studies | 22% ± 6% | |
neuron | 4 studies | 24% ± 7% | |
smooth muscle cell | 4 studies | 18% ± 3% | |
fibroblast | 4 studies | 21% ± 5% | |
pro-B cell | 4 studies | 27% ± 3% | |
GABAergic neuron | 4 studies | 35% ± 11% | |
glutamatergic neuron | 4 studies | 43% ± 13% | |
oligodendrocyte | 4 studies | 20% ± 4% | |
plasmablast | 3 studies | 41% ± 13% | |
lymphocyte | 3 studies | 18% ± 1% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 18% ± 2% | |
ciliated cell | 3 studies | 19% ± 3% | |
dendritic cell | 3 studies | 28% ± 2% | |
abnormal cell | 3 studies | 24% ± 6% | |
basal cell | 3 studies | 24% ± 6% | |
transit amplifying cell | 3 studies | 30% ± 5% | |
macrophage | 3 studies | 19% ± 4% | |
effector CD8-positive, alpha-beta T cell | 3 studies | 27% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
skin | 100% | 5597.01 | 1808 / 1809 | 100% | 123.43 | 472 / 472 |
uterus | 100% | 5121.55 | 170 / 170 | 100% | 153.08 | 458 / 459 |
breast | 100% | 3819.08 | 459 / 459 | 100% | 108.55 | 1115 / 1118 |
stomach | 100% | 4819.21 | 358 / 359 | 100% | 89.47 | 286 / 286 |
thymus | 100% | 5406.68 | 653 / 653 | 100% | 111.07 | 603 / 605 |
bladder | 100% | 6564.52 | 21 / 21 | 100% | 123.73 | 502 / 504 |
lung | 100% | 3932.27 | 576 / 578 | 100% | 92.75 | 1153 / 1155 |
esophagus | 100% | 6637.94 | 1445 / 1445 | 99% | 66.26 | 182 / 183 |
brain | 99% | 3635.02 | 2624 / 2642 | 100% | 90.91 | 705 / 705 |
intestine | 100% | 7794.09 | 966 / 966 | 99% | 104.16 | 523 / 527 |
prostate | 100% | 3953.07 | 245 / 245 | 99% | 69.97 | 498 / 502 |
ovary | 100% | 3366.45 | 180 / 180 | 97% | 58.09 | 419 / 430 |
kidney | 100% | 2598.71 | 89 / 89 | 96% | 47.51 | 864 / 901 |
adrenal gland | 100% | 3168.22 | 258 / 258 | 93% | 63.93 | 214 / 230 |
pancreas | 93% | 1505.56 | 304 / 328 | 99% | 79.85 | 176 / 178 |
liver | 94% | 1632.00 | 212 / 226 | 98% | 58.11 | 396 / 406 |
adipose | 100% | 3983.54 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 155.70 | 29 / 29 |
spleen | 100% | 4960.02 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 145.62 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 67.22 | 1 / 1 |
blood vessel | 100% | 5150.81 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 2891.15 | 796 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 68.65 | 79 / 80 |
heart | 96% | 2693.84 | 825 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 81% | 3166.80 | 750 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0016925 | Biological process | protein sumoylation |
GO_0033235 | Biological process | positive regulation of protein sumoylation |
GO_1903955 | Biological process | positive regulation of protein targeting to mitochondrion |
GO_0031510 | Cellular component | SUMO activating enzyme complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0008047 | Molecular function | enzyme activator activity |
GO_0043008 | Molecular function | ATP-dependent protein binding |
GO_0004839 | Molecular function | ubiquitin activating enzyme activity |
GO_0019948 | Molecular function | SUMO activating enzyme activity |
GO_0044388 | Molecular function | small protein activating enzyme binding |
GO_0005515 | Molecular function | protein binding |
Gene name | SAE1 |
Protein name | SUMO-1 activating enzyme subunit 1, isoform CRA_a (SUMO1 activating enzyme subunit 1) (cDNA FLJ14689 fis, clone NT2RP2005204, highly similar to Ubiquitin-like 1-activating enzyme E1A) SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] SUMO1 activating enzyme subunit 1 |
Synonyms | UBLE1A SUA1 hCG_20373 AOS1 |
Description | FUNCTION: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. . |
Accessions | ENST00000600706.5 ENST00000659110.1 ENST00000594144.5 Q9UBE0 B3KNJ4 M0R286 ENST00000594526.5 M0QYM8 ENST00000664120.1 ENST00000413379.7 [Q9UBE0-3] M0R054 M0QYP2 ENST00000414294.6 ENST00000392776.3 [Q9UBE0-2] A0A590UKC5 ENST00000660039.1 M0QZS6 M0R375 ENST00000270225.12 [Q9UBE0-1] ENST00000596995.1 A0A590UK93 A0A590UKA0 ENST00000598840.5 M0QX65 ENST00000600753.1 ENST00000597808.5 |