Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 12 studies | 23% ± 7% | |
| CD8-positive, alpha-beta T cell | 8 studies | 24% ± 6% | |
| CD4-positive, alpha-beta T cell | 7 studies | 29% ± 10% | |
| epithelial cell | 6 studies | 28% ± 10% | |
| natural killer cell | 6 studies | 28% ± 8% | |
| myofibroblast cell | 5 studies | 18% ± 3% | |
| pericyte | 5 studies | 17% ± 3% | |
| regulatory T cell | 5 studies | 21% ± 4% | |
| astrocyte | 5 studies | 23% ± 7% | |
| T cell | 5 studies | 22% ± 4% | |
| B cell | 4 studies | 19% ± 5% | |
| hematopoietic precursor cell | 4 studies | 24% ± 4% | |
| connective tissue cell | 4 studies | 22% ± 6% | |
| neuron | 4 studies | 24% ± 7% | |
| smooth muscle cell | 4 studies | 18% ± 3% | |
| fibroblast | 4 studies | 21% ± 5% | |
| pro-B cell | 4 studies | 27% ± 3% | |
| GABAergic neuron | 4 studies | 35% ± 11% | |
| glutamatergic neuron | 4 studies | 43% ± 13% | |
| oligodendrocyte | 4 studies | 20% ± 4% | |
| plasmablast | 3 studies | 41% ± 13% | |
| lymphocyte | 3 studies | 18% ± 1% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 18% ± 2% | |
| ciliated cell | 3 studies | 19% ± 3% | |
| dendritic cell | 3 studies | 28% ± 2% | |
| abnormal cell | 3 studies | 24% ± 6% | |
| basal cell | 3 studies | 24% ± 6% | |
| transit amplifying cell | 3 studies | 30% ± 5% | |
| macrophage | 3 studies | 19% ± 4% | |
| effector CD8-positive, alpha-beta T cell | 3 studies | 27% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 100% | 5597.01 | 1808 / 1809 | 100% | 123.43 | 472 / 472 |
| uterus | 100% | 5121.55 | 170 / 170 | 100% | 153.08 | 458 / 459 |
| breast | 100% | 3819.08 | 459 / 459 | 100% | 108.55 | 1115 / 1118 |
| stomach | 100% | 4819.21 | 358 / 359 | 100% | 89.47 | 286 / 286 |
| thymus | 100% | 5406.68 | 653 / 653 | 100% | 111.07 | 603 / 605 |
| bladder | 100% | 6564.52 | 21 / 21 | 100% | 123.73 | 502 / 504 |
| lung | 100% | 3932.27 | 576 / 578 | 100% | 92.75 | 1153 / 1155 |
| esophagus | 100% | 6637.94 | 1445 / 1445 | 99% | 66.26 | 182 / 183 |
| brain | 99% | 3635.02 | 2624 / 2642 | 100% | 90.91 | 705 / 705 |
| intestine | 100% | 7794.09 | 966 / 966 | 99% | 104.16 | 523 / 527 |
| prostate | 100% | 3953.07 | 245 / 245 | 99% | 69.97 | 498 / 502 |
| ovary | 100% | 3366.45 | 180 / 180 | 97% | 58.09 | 419 / 430 |
| kidney | 100% | 2598.71 | 89 / 89 | 96% | 47.51 | 864 / 901 |
| adrenal gland | 100% | 3168.22 | 258 / 258 | 93% | 63.93 | 214 / 230 |
| pancreas | 93% | 1505.56 | 304 / 328 | 99% | 79.85 | 176 / 178 |
| liver | 94% | 1632.00 | 212 / 226 | 98% | 58.11 | 396 / 406 |
| adipose | 100% | 3983.54 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 155.70 | 29 / 29 |
| spleen | 100% | 4960.02 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 145.62 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 67.22 | 1 / 1 |
| blood vessel | 100% | 5150.81 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 2891.15 | 796 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 68.65 | 79 / 80 |
| heart | 96% | 2693.84 | 825 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 81% | 3166.80 | 750 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0016925 | Biological process | protein sumoylation |
| GO_0033235 | Biological process | positive regulation of protein sumoylation |
| GO_1903955 | Biological process | positive regulation of protein targeting to mitochondrion |
| GO_0031510 | Cellular component | SUMO activating enzyme complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0008047 | Molecular function | enzyme activator activity |
| GO_0043008 | Molecular function | ATP-dependent protein binding |
| GO_0004839 | Molecular function | ubiquitin activating enzyme activity |
| GO_0019948 | Molecular function | SUMO activating enzyme activity |
| GO_0044388 | Molecular function | small protein activating enzyme binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SAE1 |
| Protein name | SUMO-1 activating enzyme subunit 1, isoform CRA_a (SUMO1 activating enzyme subunit 1) (cDNA FLJ14689 fis, clone NT2RP2005204, highly similar to Ubiquitin-like 1-activating enzyme E1A) SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] SUMO1 activating enzyme subunit 1 |
| Synonyms | UBLE1A SUA1 hCG_20373 AOS1 |
| Description | FUNCTION: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. . |
| Accessions | ENST00000600706.5 ENST00000659110.1 ENST00000594144.5 Q9UBE0 B3KNJ4 M0R286 ENST00000594526.5 M0QYM8 ENST00000664120.1 ENST00000413379.7 [Q9UBE0-3] M0R054 M0QYP2 ENST00000414294.6 ENST00000392776.3 [Q9UBE0-2] A0A590UKC5 ENST00000660039.1 M0QZS6 M0R375 ENST00000270225.12 [Q9UBE0-1] ENST00000596995.1 A0A590UK93 A0A590UKA0 ENST00000598840.5 M0QX65 ENST00000600753.1 ENST00000597808.5 |