S100B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007611Biological processlearning or memory
GO_0007155Biological processcell adhesion
GO_1990845Biological processadaptive thermogenesis
GO_0007409Biological processaxonogenesis
GO_0048168Biological processregulation of neuronal synaptic plasticity
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0007417Biological processcentral nervous system development
GO_0007613Biological processmemory
GO_0097490Biological processsympathetic neuron projection extension
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0001726Cellular componentruffle
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0008270Molecular functionzinc ion binding
GO_0048156Molecular functiontau protein binding
GO_0044548Molecular functionS100 protein binding
GO_0050786Molecular functionRAGE receptor binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameS100B
Protein nameS100 calcium binding protein B
Protein S100 (S100 calcium-binding protein)
Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)
Synonyms
DescriptionFUNCTION: Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain . Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer . Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (By similarity). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (By similarity). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization . May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity . .

AccessionsP04271
A8MRB1
A0A0S2Z4C5
ENST00000291700.9
ENST00000367071.4
ENST00000397648.1