RNF31 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RNF31 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNF31 at tissue level.

III. Associated gene sets

GO_0023035Biological processCD40 signaling pathway
GO_0000209Biological processprotein polyubiquitination
GO_0050852Biological processT cell receptor signaling pathway
GO_1904417Biological processpositive regulation of xenophagy
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0060546Biological processnegative regulation of necroptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0042742Biological processdefense response to bacterium
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0097039Biological processprotein linear polyubiquitination
GO_0071797Cellular componentLUBAC complex
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0035631Cellular componentCD40 receptor complex
GO_0005829Cellular componentcytosol
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_1990450Molecular functionlinear polyubiquitin binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0036435Molecular functionK48-linked polyubiquitin modification-dependent protein binding
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameRNF31
Protein nameRing finger protein 31
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
RBR-type E3 ubiquitin transferase (EC 2.3.2.31)
SynonymsZIBRA
DescriptionFUNCTION: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation . LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways . Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation . LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex . The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria . LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin . Recruited to the surface of bacteria by RNF213, which initiates the bacterial ubiquitin coat . The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation . Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis . RNF31 is required for linear ubiquitination of BCL10, thereby promoting TCR-induced NF-kappa-B activation . Binds polyubiquitin of different linkage types . .

AccessionsH0YNT1
ENST00000699885.1
ENST00000560875.1
ENST00000647495.2 [Q96EP0-1]
ENST00000560787.5
ENST00000559275.5 [Q96EP0-3]
ENST00000483895.5
ENST00000559308.5
ENST00000699887.1
ENST00000559719.1
H0YNK5
A0A8V8TQR2
ENST00000559533.6
H0YMG4
H0YKI4
H0YKX0
Q96EP0
A0A8V8TPI3
ENST00000560071.5
A0A8V8TQD3
H0YM57
H0YNJ0
ENST00000559260.5
H0YMN0
ENST00000559449.5
ENST00000324103.11 [Q96EP0-1]
H0YM13
H0YMG8
ENST00000642631.1 [Q96EP0-3]
ENST00000699886.1
H0YNC1
ENST00000491351.6
ENST00000557991.5
ENST00000558907.6
H0YMK6