RNF19B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNF19B at tissue level.

III. Associated gene sets

GO_0002250Biological processadaptive immune response
GO_0051865Biological processprotein autoubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0000209Biological processprotein polyubiquitination
GO_0042267Biological processnatural killer cell mediated cytotoxicity
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0000151Cellular componentubiquitin ligase complex
GO_0044194Cellular componentcytolytic granule
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0031624Molecular functionubiquitin conjugating enzyme binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameRNF19B
Protein nameE3 ubiquitin-protein ligase RNF19B (EC 2.3.2.31) (IBR domain-containing protein 3) (Natural killer lytic-associated molecule) (RING finger protein 19B)
SynonymsIBRDC3
NKLAM
DescriptionFUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 . Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells . Protects against staurosporin-induced cell death . .

AccessionsQ6ZMZ0
ENST00000356990.9 [Q6ZMZ0-2]
ENST00000373456.11 [Q6ZMZ0-1]
ENST00000235150.5 [Q6ZMZ0-4]