RNF185 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060340Biological processpositive regulation of type I interferon-mediated signaling pathway
GO_0055085Biological processtransmembrane transport
GO_0045087Biological processinnate immune response
GO_0051607Biological processdefense response to virus
GO_0051865Biological processprotein autoubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0045089Biological processpositive regulation of innate immune response
GO_0044314Biological processprotein K27-linked ubiquitination
GO_0006914Biological processautophagy
GO_1904294Biological processpositive regulation of ERAD pathway
GO_0036503Biological processERAD pathway
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005741Cellular componentmitochondrial outer membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0046872Molecular functionmetal ion binding
GO_0044390Molecular functionubiquitin-like protein conjugating enzyme binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameRNF185
Protein nameE3 ubiquitin-protein ligase RNF185 (EC 2.3.2.27) (RING finger protein 185)
Ring finger protein 185, isoform CRA_h (cDNA FLJ53598, moderately similar to RING finger protein 185)
SynonymshCG_2010785
DescriptionFUNCTION: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 . Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation . Protects cells from ER stress-induced apoptosis . Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway . Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS at 'Lys-173' and 'Lys-384', thereby promoting CGAS cyclic GMP-AMP synthase activity . Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 . .

AccessionsENST00000326132.11 [Q96GF1-1]
B4DMD6
ENST00000266252.8 [Q96GF1-2]
ENST00000518626.5 [Q96GF1-1]
Q96GF1