RC3H2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043029Biological processT cell homeostasis
GO_0048286Biological processlung alveolus development
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0000209Biological processprotein polyubiquitination
GO_0009791Biological processpost-embryonic development
GO_0042098Biological processT cell proliferation
GO_0048535Biological processlymph node development
GO_0060173Biological processlimb development
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0035264Biological processmulticellular organism growth
GO_0001782Biological processB cell homeostasis
GO_0050852Biological processT cell receptor signaling pathway
GO_0048536Biological processspleen development
GO_2000320Biological processnegative regulation of T-helper 17 cell differentiation
GO_0061470Biological processT follicular helper cell differentiation
GO_2000628Biological processregulation of miRNA metabolic process
GO_0000288Biological processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0016020Cellular componentmembrane
GO_0000932Cellular componentP-body
GO_0009986Cellular componentcell surface
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010494Cellular componentcytoplasmic stress granule
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0003729Molecular functionmRNA binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0035613Molecular functionRNA stem-loop binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameRC3H2
Protein nameRing finger and CCCH-type domains 2
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)
SynonymsMNAB
RNF164
DescriptionFUNCTION: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation (By similarity). miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression . Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains . Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains . Involved in the ubiquitination of MAP3K5 . Able to interact with double-stranded RNA (dsRNA) . .

AccessionsH0Y5D9
Q4VXB2
ENST00000357244.7 [Q9HBD1-1]
Q9HBD1
ENST00000498479.5 [Q9HBD1-2]
A6NHN2
ENST00000373670.5 [Q9HBD1-1]
ENST00000454740.5
ENST00000471874.2 [Q9HBD1-5]
ENST00000398671.2
ENST00000335387.9
ENST00000423239.6 [Q9HBD1-4]