RBM15B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RBM15B at tissue level.

III. Associated gene sets

GO_0006913Biological processnucleocytoplasmic transport
GO_0006406Biological processmRNA export from nucleus
GO_0009048Biological processdosage compensation by inactivation of X chromosome
GO_0001510Biological processRNA methylation
GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0016607Cellular componentnuclear speck
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0036396Cellular componentRNA N6-methyladenosine methyltransferase complex
GO_0005635Cellular componentnuclear envelope
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameRBM15B
Protein nameRBM15B protein
Alternative protein RBM15B
Putative RNA-binding protein 15B (One-twenty two protein 3) (HsOTT3) (HuOTT3) (RNA-binding motif protein 15B)
SynonymsOTT3
DescriptionFUNCTION: RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA . Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex . Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist . Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation . Inhibits pre-mRNA splicing . Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 . .

AccessionsQ8NDT2
L8EAN0
ENST00000563281.2 [Q8NDT2-1]
Q0VA89