RBM15 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RBM15 at tissue level.

III. Associated gene sets

GO_0009048Biological processdosage compensation by inactivation of X chromosome
GO_0045638Biological processnegative regulation of myeloid cell differentiation
GO_0001510Biological processRNA methylation
GO_0045652Biological processregulation of megakaryocyte differentiation
GO_0038163Biological processthrombopoietin-mediated signaling pathway
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0048536Biological processspleen development
GO_0007221Biological processpositive regulation of transcription of Notch receptor target
GO_0001569Biological processbranching involved in blood vessel morphogenesis
GO_0060674Biological processplacenta blood vessel development
GO_0060412Biological processventricular septum morphogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0036396Cellular componentRNA N6-methyladenosine methyltransferase complex
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRBM15
Protein nameRNA binding motif protein 15
RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15)
SynonymsOTT1
OTT
DescriptionFUNCTION: RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA . Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (By similarity). Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex . Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist . Required for the development of multiple tissues, such as the maintenance of the homeostasis of long-term hematopoietic stem cells and for megakaryocyte (MK) and B-cell differentiation (By similarity). Regulates megakaryocyte differentiation by regulating alternative splicing of genes important for megakaryocyte differentiation; probably regulates alternative splicing via m6A regulation . Required for placental vascular branching morphogenesis and embryonic development of the heart and spleen (By similarity). Acts as a regulator of thrombopoietin response in hematopoietic stem cells by regulating alternative splicing of MPL (By similarity). May also function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing . High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing . May be implicated in HOX gene regulation . .

AccessionsA0A499FJY3
ENST00000654015.1
ENST00000369784.9 [Q96T37-1]
ENST00000652342.2 [Q96T37-4]
A0A087WWP4
ENST00000487146.8 [Q96T37-3]
ENST00000652747.1 [Q96T37-3]
ENST00000650953.2
Q96T37
ENST00000602849.1 [Q96T37-2]
ENST00000618772.4 [Q96T37-1]
A0A494C001
ENST00000617047.1