RAD51D report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RAD51D at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RAD51D at tissue level.

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0036297Biological processinterstrand cross-link repair
GO_0007131Biological processreciprocal meiotic recombination
GO_0000722Biological processtelomere maintenance via recombination
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0000723Biological processtelomere maintenance
GO_0042148Biological processDNA strand invasion
GO_0051726Biological processregulation of cell cycle
GO_0005813Cellular componentcentrosome
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0033063Cellular componentRad51B-Rad51C-Rad51D-XRCC2 complex
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0043015Molecular functiongamma-tubulin binding
GO_0003677Molecular functionDNA binding
GO_0140664Molecular functionATP-dependent DNA damage sensor activity
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0000400Molecular functionfour-way junction DNA binding
GO_0005524Molecular functionATP binding
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameRAD51D
Protein nameRAD51 paralog D
HCG1989222, isoform CRA_i (RAD51 paralog D)
HCG1989222, isoform CRA_a (RAD51 paralog D) (RAD51L3 protein) (cDNA FLJ53480, highly similar to DNA repair protein RAD51 homolog 4)
DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD)
SynonymshCG_1989222
RAD51L3
DescriptionFUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM. .

AccessionsK7EKG7
ENST00000586210.5
ENST00000592850.5
ENST00000592577.6
H0UID0
ENST00000586186.3 [O75771-4]
ENST00000345365.11 [O75771-1]
K7ESL4
K7ERM7
ENST00000586044.5 [O75771-2]
Q7Z790
ENST00000335858.11 [O75771-3]
ENST00000585343.5
ENST00000460118.6
ENST00000587405.6
ENST00000588594.5 [O75771-2]
ENST00000394589.8 [O75771-1]
ENST00000588372.5
K7ESI1
ENST00000586186.2
ENST00000590016.6 [O75771-8]
O75771
ENST00000587977.5 [O75771-6]