I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| neuron | 4 studies | 35% ± 18% | |
| glutamatergic neuron | 3 studies | 24% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| neuron | 4 studies | 35% ± 18% | |
| glutamatergic neuron | 3 studies | 24% ± 7% |
Insufficient scRNA-seq data for expression of RAC3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 1203.76 | 2612 / 2642 | 98% | 62.05 | 690 / 705 |
| breast | 100% | 639.70 | 457 / 459 | 96% | 51.67 | 1075 / 1118 |
| prostate | 95% | 517.55 | 232 / 245 | 99% | 72.62 | 498 / 502 |
| skin | 97% | 433.15 | 1758 / 1809 | 90% | 53.23 | 423 / 472 |
| liver | 91% | 442.20 | 206 / 226 | 82% | 28.93 | 334 / 406 |
| ovary | 75% | 186.19 | 135 / 180 | 95% | 39.92 | 407 / 430 |
| adrenal gland | 88% | 205.16 | 228 / 258 | 70% | 22.06 | 162 / 230 |
| lung | 72% | 168.72 | 417 / 578 | 82% | 35.10 | 944 / 1155 |
| thymus | 99% | 465.65 | 648 / 653 | 44% | 8.59 | 268 / 605 |
| uterus | 51% | 113.41 | 87 / 170 | 89% | 47.13 | 410 / 459 |
| bladder | 62% | 125.00 | 13 / 21 | 77% | 30.45 | 389 / 504 |
| stomach | 84% | 363.50 | 303 / 359 | 47% | 12.01 | 134 / 286 |
| kidney | 97% | 365.78 | 86 / 89 | 32% | 5.88 | 285 / 901 |
| intestine | 69% | 157.45 | 666 / 966 | 45% | 10.89 | 237 / 527 |
| esophagus | 58% | 191.27 | 843 / 1445 | 46% | 11.19 | 85 / 183 |
| eye | 0% | 0 | 0 / 0 | 100% | 67.57 | 80 / 80 |
| ureter | 0% | 0 | 0 / 0 | 100% | 28.11 | 1 / 1 |
| pancreas | 41% | 76.84 | 134 / 328 | 58% | 12.09 | 103 / 178 |
| adipose | 98% | 548.03 | 1179 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 26.30 | 40 / 45 |
| spleen | 22% | 34.76 | 52 / 241 | 0% | 0 | 0 / 0 |
| heart | 21% | 34.33 | 177 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 2.41 | 5 / 29 |
| blood vessel | 13% | 29.22 | 174 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 12% | 19.32 | 108 / 929 | 0% | 0 | 0 / 0 |
| muscle | 3% | 5.84 | 28 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0033630 | Biological process | positive regulation of cell adhesion mediated by integrin |
| GO_0045730 | Biological process | respiratory burst |
| GO_1902622 | Biological process | regulation of neutrophil migration |
| GO_0007163 | Biological process | establishment or maintenance of cell polarity |
| GO_0050885 | Biological process | neuromuscular process controlling balance |
| GO_0030031 | Biological process | cell projection assembly |
| GO_0098974 | Biological process | postsynaptic actin cytoskeleton organization |
| GO_0048873 | Biological process | homeostasis of number of cells within a tissue |
| GO_0030865 | Biological process | cortical cytoskeleton organization |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0014041 | Biological process | regulation of neuron maturation |
| GO_0016601 | Biological process | Rac protein signal transduction |
| GO_0007015 | Biological process | actin filament organization |
| GO_0021894 | Biological process | cerebral cortex GABAergic interneuron development |
| GO_1900026 | Biological process | positive regulation of substrate adhesion-dependent cell spreading |
| GO_0008045 | Biological process | motor neuron axon guidance |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_0051932 | Biological process | synaptic transmission, GABAergic |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_0043652 | Biological process | engulfment of apoptotic cell |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0031941 | Cellular component | filamentous actin |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0012505 | Cellular component | endomembrane system |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0043020 | Cellular component | NADPH oxidase complex |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0043005 | Cellular component | neuron projection |
| GO_0005829 | Cellular component | cytosol |
| GO_0071944 | Cellular component | cell periphery |
| GO_0030426 | Cellular component | growth cone |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0003925 | Molecular function | G protein activity |
| GO_0005525 | Molecular function | GTP binding |
| GO_0048306 | Molecular function | calcium-dependent protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003924 | Molecular function | GTPase activity |
| Gene name | RAC3 |
| Protein name | Rac family small GTPase 3 Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3) |
| Synonyms | |
| Description | FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. . |
| Accessions | J3KSC4 P60763 ENST00000306897.9 J3QLK0 ENST00000580965.5 ENST00000584341.1 |
