RAB3A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	8 studies	31% ± 17%	Explore
neuron	6 studies	44% ± 21%	Explore
GABAergic neuron	5 studies	32% ± 13%	Explore
retinal ganglion cell	4 studies	84% ± 21%	Explore
retinal cone cell	4 studies	51% ± 17%	Explore
retinal rod cell	4 studies	28% ± 10%	Explore
amacrine cell	4 studies	64% ± 24%	Explore
retina horizontal cell	4 studies	46% ± 19%	Explore
interneuron	4 studies	22% ± 9%	Explore
retinal bipolar neuron	3 studies	52% ± 23%	Explore
OFF-bipolar cell	3 studies	57% ± 30%	Explore
ON-bipolar cell	3 studies	57% ± 30%	Explore
GABAergic amacrine cell	3 studies	53% ± 24%	Explore
glycinergic amacrine cell	3 studies	47% ± 21%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	27% ± 13%	Explore
eye	5 studies	37% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	96%	12231.00	2539 / 2642	100%	95.68	703 / 705
ovary	63%	1510.72	114 / 180	97%	15.36	418 / 430
adrenal gland	33%	472.04	84 / 258	99%	114.44	228 / 230
prostate	4%	35.82	9 / 245	98%	15.29	494 / 502
eye	0%	0	0 / 0	100%	28.76	80 / 80
ureter	0%	0	0 / 0	100%	9.70	1 / 1
skin	1%	11.61	25 / 1809	96%	19.25	451 / 472
breast	0%	2.57	1 / 459	92%	13.93	1032 / 1118
kidney	4%	39.20	4 / 89	87%	10.25	782 / 901
thymus	1%	5.13	4 / 653	80%	6.22	482 / 605
pancreas	0%	0	0 / 328	73%	7.95	130 / 178
heart	69%	995.18	592 / 861	0%	0	0 / 0
lung	1%	7.98	5 / 578	65%	5.12	756 / 1155
tonsil	0%	0	0 / 0	62%	4.20	28 / 45
intestine	7%	63.99	63 / 966	55%	4.84	292 / 527
uterus	1%	9.78	2 / 170	60%	5.80	277 / 459
bladder	0%	0	0 / 21	60%	5.21	304 / 504
stomach	2%	14.71	6 / 359	57%	4.65	163 / 286
liver	0%	0	0 / 226	55%	4.27	223 / 406
esophagus	4%	40.16	60 / 1445	47%	3.64	86 / 183
lymph node	0%	0	0 / 0	38%	2.74	11 / 29
blood vessel	9%	120.71	126 / 1335	0%	0	0 / 0
muscle	2%	17.45	16 / 803	0%	0	0 / 0
adipose	1%	9.78	14 / 1204	0%	0	0 / 0
peripheral blood	1%	9.89	10 / 929	0%	0	0 / 0
spleen	0%	4.59	1 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001778	Biological process	plasma membrane repair
GO_0016188	Biological process	synaptic vesicle maturation
GO_0036465	Biological process	synaptic vesicle recycling
GO_0030324	Biological process	lung development
GO_0099161	Biological process	regulation of presynaptic dense core granule exocytosis
GO_0009791	Biological process	post-embryonic development
GO_1905684	Biological process	regulation of plasma membrane repair
GO_0051602	Biological process	response to electrical stimulus
GO_0017156	Biological process	calcium-ion regulated exocytosis
GO_0048489	Biological process	synaptic vesicle transport
GO_0031630	Biological process	regulation of synaptic vesicle fusion to presynaptic active zone membrane
GO_0016079	Biological process	synaptic vesicle exocytosis
GO_0007274	Biological process	neuromuscular synaptic transmission
GO_0009306	Biological process	protein secretion
GO_1903307	Biological process	positive regulation of regulated secretory pathway
GO_0048790	Biological process	maintenance of presynaptic active zone structure
GO_0060478	Biological process	acrosomal vesicle exocytosis
GO_0007409	Biological process	axonogenesis
GO_0045055	Biological process	regulated exocytosis
GO_0007005	Biological process	mitochondrion organization
GO_0006887	Biological process	exocytosis
GO_0032418	Biological process	lysosome localization
GO_0003016	Biological process	respiratory system process
GO_0050975	Biological process	sensory perception of touch
GO_0045054	Biological process	constitutive secretory pathway
GO_0030073	Biological process	insulin secretion
GO_0097091	Biological process	synaptic vesicle clustering
GO_0061670	Biological process	evoked neurotransmitter secretion
GO_0048172	Biological process	regulation of short-term neuronal synaptic plasticity
GO_0045921	Biological process	positive regulation of exocytosis
GO_0060201	Cellular component	clathrin-sculpted acetylcholine transport vesicle membrane
GO_0030667	Cellular component	secretory granule membrane
GO_0098793	Cellular component	presynapse
GO_0060203	Cellular component	clathrin-sculpted glutamate transport vesicle membrane
GO_0001669	Cellular component	acrosomal vesicle
GO_0061202	Cellular component	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO_0005886	Cellular component	plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0043195	Cellular component	terminal bouton
GO_0005764	Cellular component	lysosome
GO_0030672	Cellular component	synaptic vesicle membrane
GO_1903561	Cellular component	extracellular vesicle
GO_0098794	Cellular component	postsynapse
GO_0048786	Cellular component	presynaptic active zone
GO_0005829	Cellular component	cytosol
GO_0008021	Cellular component	synaptic vesicle
GO_0070083	Cellular component	clathrin-sculpted monoamine transport vesicle membrane
GO_0030424	Cellular component	axon
GO_0005768	Cellular component	endosome
GO_0030742	Molecular function	GTP-dependent protein binding
GO_0031489	Molecular function	myosin V binding
GO_0005525	Molecular function	GTP binding
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RAB3A
Protein name	Ras-related protein Rab-3A RAB3A, member RAS oncogene family
Synonyms
Description	FUNCTION: Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 . Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 . Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity). Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction (By similarity). .
Accessions	P20336 ENST00000481914.2 S4R3Q3 ENST00000222256.9 M0R257 ENST00000464076.3

RAB3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review