Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 24% ± 7% | |
GABAergic neuron | 6 studies | 35% ± 20% | |
glutamatergic neuron | 5 studies | 45% ± 22% | |
epithelial cell | 5 studies | 31% ± 9% | |
adipocyte | 5 studies | 20% ± 4% | |
astrocyte | 5 studies | 25% ± 5% | |
naive B cell | 4 studies | 16% ± 1% | |
B cell | 4 studies | 16% ± 1% | |
myeloid cell | 4 studies | 17% ± 1% | |
oligodendrocyte precursor cell | 4 studies | 26% ± 4% | |
natural killer cell | 4 studies | 16% ± 1% | |
macrophage | 4 studies | 21% ± 3% | |
gamma-delta T cell | 4 studies | 18% ± 3% | |
goblet cell | 4 studies | 27% ± 15% | |
interneuron | 4 studies | 36% ± 20% | |
oligodendrocyte | 4 studies | 22% ± 3% | |
microglial cell | 3 studies | 22% ± 1% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 17% ± 1% | |
ciliated cell | 3 studies | 21% ± 2% | |
abnormal cell | 3 studies | 23% ± 6% | |
type I pneumocyte | 3 studies | 17% ± 2% | |
endothelial cell of lymphatic vessel | 3 studies | 21% ± 4% | |
monocyte | 3 studies | 18% ± 3% | |
fibroblast | 3 studies | 19% ± 4% | |
lymphocyte | 3 studies | 22% ± 3% | |
transit amplifying cell | 3 studies | 25% ± 10% | |
neuron | 3 studies | 25% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 4892.43 | 21 / 21 | 100% | 42.12 | 504 / 504 |
esophagus | 100% | 4744.22 | 1445 / 1445 | 100% | 43.97 | 183 / 183 |
intestine | 100% | 5301.98 | 966 / 966 | 100% | 40.70 | 527 / 527 |
lung | 100% | 5467.83 | 578 / 578 | 100% | 40.43 | 1155 / 1155 |
ovary | 100% | 4892.60 | 180 / 180 | 100% | 57.94 | 430 / 430 |
prostate | 100% | 4925.44 | 245 / 245 | 100% | 46.82 | 502 / 502 |
skin | 100% | 6554.46 | 1809 / 1809 | 100% | 51.49 | 472 / 472 |
stomach | 100% | 4003.89 | 359 / 359 | 100% | 42.44 | 286 / 286 |
uterus | 100% | 5404.95 | 170 / 170 | 100% | 43.82 | 459 / 459 |
breast | 100% | 5842.58 | 459 / 459 | 100% | 54.29 | 1117 / 1118 |
thymus | 100% | 5411.72 | 653 / 653 | 100% | 47.87 | 603 / 605 |
pancreas | 100% | 2568.73 | 328 / 328 | 99% | 38.63 | 177 / 178 |
kidney | 100% | 3468.36 | 89 / 89 | 99% | 31.06 | 893 / 901 |
liver | 100% | 2362.16 | 226 / 226 | 99% | 23.61 | 400 / 406 |
adrenal gland | 100% | 5156.45 | 258 / 258 | 98% | 33.07 | 226 / 230 |
brain | 98% | 3188.66 | 2583 / 2642 | 100% | 52.84 | 705 / 705 |
adipose | 100% | 5400.46 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 28.85 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 49.22 | 29 / 29 |
spleen | 100% | 7192.18 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 42.75 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 21.42 | 1 / 1 |
blood vessel | 100% | 4929.24 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 3513.90 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 2631.93 | 848 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 95% | 3319.09 | 885 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0030968 | Biological process | endoplasmic reticulum unfolded protein response |
GO_0070059 | Biological process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0036499 | Biological process | PERK-mediated unfolded protein response |
GO_0140467 | Biological process | integrated stress response signaling |
GO_0034976 | Biological process | response to endoplasmic reticulum stress |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0005515 | Molecular function | protein binding |
Gene name | QRICH1 |
Protein name | Alternative protein QRICH1 Transcriptional regulator QRICH1 (Glutamine-rich protein 1) Glutamine rich 1 (HCG2002013, isoform CRA_b) Glutamine rich 1 Glutamine-rich 1 (HCG2002013, isoform CRA_c) (cDNA FLJ77780) |
Synonyms | hCG_2002013 |
Description | FUNCTION: Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress . Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway . ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR . May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability . Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver . Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth . . |
Accessions | ENST00000430979.1 ENST00000703939.1 ENST00000703942.1 ENST00000703940.1 C9JIA8 A0A994J6Q4 A0A994J457 ENST00000411682.2 ENST00000357496.6 C9JAL2 A0A994J492 A0A994J4P1 ENST00000424300.5 A0A994J424 ENST00000395443.7 Q2TAL8 ENST00000703873.1 L8E8D2 ENST00000437939.5 ENST00000703943.1 ENST00000703941.1 A0A994J4K3 A0A994J751 ENST00000703872.1 ENST00000703938.1 A1L3Z9 ENST00000703871.1 |