QRICH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043065Biological processpositive regulation of apoptotic process
GO_0036499Biological processPERK-mediated unfolded protein response
GO_0140467Biological processintegrated stress response signaling
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameQRICH1
Protein nameAlternative protein QRICH1
Transcriptional regulator QRICH1 (Glutamine-rich protein 1)
Glutamine rich 1 (HCG2002013, isoform CRA_b)
Glutamine rich 1
Glutamine-rich 1 (HCG2002013, isoform CRA_c) (cDNA FLJ77780)
SynonymshCG_2002013
DescriptionFUNCTION: Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress . Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway . ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR . May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability . Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver . Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth . .

AccessionsENST00000430979.1
ENST00000703939.1
ENST00000703942.1
ENST00000703940.1
C9JIA8
A0A994J6Q4
A0A994J457
ENST00000411682.2
ENST00000357496.6
C9JAL2
A0A994J492
A0A994J4P1
ENST00000424300.5
A0A994J424
ENST00000395443.7
Q2TAL8
ENST00000703873.1
L8E8D2
ENST00000437939.5
ENST00000703943.1
ENST00000703941.1
A0A994J4K3
A0A994J751
ENST00000703872.1
ENST00000703938.1
A1L3Z9
ENST00000703871.1