PYDC1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PYDC1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PYDC1 at tissue level.

III. Associated gene sets

GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_2000660Biological processnegative regulation of interleukin-1-mediated signaling pathway
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_1900226Biological processnegative regulation of NLRP3 inflammasome complex assembly
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0045087Biological processinnate immune response
GO_0008385Cellular componentIkappaB kinase complex
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0120283Molecular functionprotein serine/threonine kinase binding
GO_0030291Molecular functionprotein serine/threonine kinase inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePYDC1
Protein namePyrin domain-containing protein 1 (PAAD-only protein 1) (Pyrin-only protein 1) (cellular POP1) (cPOP1)
SynonymsASCI
ASC2
POP1
PYC1
DescriptionFUNCTION: Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. .

AccessionsENST00000302964.4
Q8WXC3