Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
skin | 99% | 1293.63 | 1794 / 1809 | 100% | 97.72 | 471 / 472 |
thymus | 100% | 1321.00 | 652 / 653 | 97% | 80.97 | 584 / 605 |
lung | 81% | 275.05 | 469 / 578 | 91% | 56.42 | 1056 / 1155 |
intestine | 56% | 306.25 | 540 / 966 | 98% | 71.14 | 517 / 527 |
stomach | 43% | 186.04 | 156 / 359 | 97% | 61.01 | 278 / 286 |
esophagus | 43% | 664.28 | 619 / 1445 | 98% | 63.52 | 179 / 183 |
bladder | 43% | 102.14 | 9 / 21 | 96% | 73.01 | 482 / 504 |
breast | 25% | 54.63 | 115 / 459 | 87% | 43.14 | 972 / 1118 |
uterus | 11% | 27.32 | 18 / 170 | 99% | 141.12 | 453 / 459 |
ovary | 8% | 22.36 | 14 / 180 | 98% | 79.57 | 421 / 430 |
lymph node | 0% | 0 | 0 / 0 | 100% | 187.24 | 29 / 29 |
tonsil | 0% | 0 | 0 / 0 | 100% | 192.71 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 22.29 | 1 / 1 |
spleen | 99% | 604.12 | 239 / 241 | 0% | 0 | 0 / 0 |
brain | 43% | 121.33 | 1141 / 2642 | 47% | 27.83 | 333 / 705 |
eye | 0% | 0 | 0 / 0 | 90% | 31.61 | 72 / 80 |
pancreas | 3% | 5.98 | 9 / 328 | 81% | 29.33 | 144 / 178 |
peripheral blood | 78% | 1538.35 | 724 / 929 | 0% | 0 | 0 / 0 |
liver | 11% | 44.40 | 25 / 226 | 60% | 24.46 | 244 / 406 |
adrenal gland | 31% | 76.48 | 81 / 258 | 38% | 16.65 | 88 / 230 |
prostate | 28% | 64.47 | 68 / 245 | 18% | 4.36 | 89 / 502 |
kidney | 19% | 57.34 | 17 / 89 | 21% | 6.03 | 192 / 901 |
adipose | 30% | 68.81 | 362 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 28% | 55.65 | 376 / 1335 | 0% | 0 | 0 / 0 |
heart | 14% | 33.44 | 124 / 861 | 0% | 0 | 0 / 0 |
muscle | 6% | 13.78 | 52 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006281 | Biological process | DNA repair |
GO_0007283 | Biological process | spermatogenesis |
GO_0051301 | Biological process | cell division |
GO_0051276 | Biological process | chromosome organization |
GO_0045143 | Biological process | homologous chromosome segregation |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0004869 | Molecular function | cysteine-type endopeptidase inhibitor activity |
GO_0140677 | Molecular function | molecular function activator activity |
GO_0005515 | Molecular function | protein binding |
GO_0017124 | Molecular function | SH3 domain binding |
Gene name | PTTG1 |
Protein name | PTTG1 protein (Pituitary tumor-transforming 1) (cDNA, FLJ92498, Homo sapiens pituitary tumor-transforming 1 (PTTG1), mRNA) Pituitary tumor-transforming protein 1 PTTG1 regulator of sister chromatid separation, securin Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) PTTG1 protein |
Synonyms | hCG_16307 TUTR1 PTTG EAP1 |
Description | FUNCTION: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. . |
Accessions | ENST00000352433.10 C4TNW4 ENST00000517480.1 E5RJR4 O95997 ENST00000520452.5 Q2VPE7 Q6IAL9 ENST00000393964.1 |