PTTG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0007283Biological processspermatogenesis
GO_0051301Biological processcell division
GO_0051276Biological processchromosome organization
GO_0045143Biological processhomologous chromosome segregation
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004869Molecular functioncysteine-type endopeptidase inhibitor activity
GO_0140677Molecular functionmolecular function activator activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene namePTTG1
Protein namePTTG1 protein (Pituitary tumor-transforming 1) (cDNA, FLJ92498, Homo sapiens pituitary tumor-transforming 1 (PTTG1), mRNA)
Pituitary tumor-transforming protein 1
PTTG1 regulator of sister chromatid separation, securin
Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG)
PTTG1 protein
SynonymshCG_16307
TUTR1
PTTG
EAP1
DescriptionFUNCTION: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. .

AccessionsENST00000352433.10
C4TNW4
ENST00000517480.1
E5RJR4
O95997
ENST00000520452.5
Q2VPE7
Q6IAL9
ENST00000393964.1