PTGR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006691Biological processleukotriene metabolic process
GO_2001302Biological processlipoxin A4 metabolic process
GO_0036102Biological processleukotriene B4 metabolic process
GO_0006693Biological processprostaglandin metabolic process
GO_0005737Cellular componentcytoplasm
GO_0070062Cellular componentextracellular exosome
GO_0036185Molecular function13-lipoxin reductase activity
GO_0036132Molecular function13-prostaglandin reductase activity
GO_0035798Molecular function2-alkenal reductase (NADPH) activity
GO_0005515Molecular functionprotein binding
GO_0047522Molecular function15-oxoprostaglandin 13-oxidase activity
GO_0097257Molecular functionleukotriene B4 12-hydroxy dehydrogenase activity

IV. Literature review

[source]
Gene namePTGR1
Protein name15-oxoprostaglandin 13-reductase (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase)
Prostaglandin reductase 1 (EC 1.3.1.48) (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (Dithiolethione-inducible gene 1 protein) (Leukotriene B4 12-hydroxydehydrogenase) (NAD(P)H-dependent alkenal/one oxidoreductase)
Prostaglandin reductase 1 (PRG-1) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (Dithiolethione-inducible gene 1 protein) (D3T-inducible gene 1 protein) (DIG-1) (Leukotriene B4 12-hydroxydehydrogenase) (NAD(P)H-dependent alkenal/one oxidoreductase) (EC 1.3.1.74)
SynonymsLTB4DH
DescriptionFUNCTION: NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX) . Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha . Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites (By similarity). Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site (By similarity). May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one . May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles (By similarity). .

AccessionsQ5JVP2
ENST00000374324.5
F2Z3J9
ENST00000407693.7 [Q14914-1]
ENST00000309195.9 [Q14914-1]
Q14914
ENST00000538962.7 [Q14914-2]
ENST00000422125.1
F6XGT7
ENST00000466771.6