PRIM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903934Biological processpositive regulation of DNA primase activity
GO_0006270Biological processDNA replication initiation
GO_0006269Biological processDNA replication, synthesis of primer
GO_1990077Cellular componentprimosome complex
GO_0005658Cellular componentalpha DNA polymerase:primase complex
GO_0005654Cellular componentnucleoplasm
GO_0003677Molecular functionDNA binding
GO_0071667Molecular functionDNA/RNA hybrid binding
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePRIM2
Protein nameDNA primase large subunit
DNA primase large subunit (DNA primase 58 kDa subunit) (p58)
Primase DNA polypeptide 2
DNA primase subunit 2
SynonymsPRIM2A
DescriptionFUNCTION: Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis . During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands . These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). In the primase complex, both subunits are necessary for the initial di-nucleotide formation, but the extension of the primer depends only on the catalytic subunit . Binds RNA:DNA duplex and coordinates the catalytic activities of PRIM1 and POLA2 during primase-to-polymerase switch. .

AccessionsENST00000671770.1
A0A5F9ZHR0
ENST00000615550.5 [P49643-1]
I0CMJ8
P49643
I0EZ64
ENST00000672107.1
H9XFA6
A0A096LP51
A0A5F9ZHU7
ENST00000370687.6 [P49643-2]
I0CMK6
ENST00000274891.10 [P49643-2]
ENST00000550475.2
H9XFA7