PRCP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	34 studies	40% ± 22%	Explore
conventional dendritic cell	22 studies	33% ± 14%	Explore
endothelial cell of lymphatic vessel	20 studies	36% ± 14%	Explore
macrophage	15 studies	24% ± 9%	Explore
astrocyte	13 studies	31% ± 14%	Explore
fibroblast	13 studies	25% ± 9%	Explore
vein endothelial cell	12 studies	61% ± 19%	Explore
endothelial cell of vascular tree	11 studies	31% ± 9%	Explore
capillary endothelial cell	10 studies	38% ± 23%	Explore
non-classical monocyte	9 studies	23% ± 10%	Explore
classical monocyte	9 studies	23% ± 8%	Explore
dendritic cell	9 studies	38% ± 19%	Explore
myeloid cell	7 studies	23% ± 7%	Explore
endothelial cell of artery	6 studies	35% ± 23%	Explore
B cell	6 studies	17% ± 1%	Explore
monocyte	6 studies	22% ± 4%	Explore
plasmacytoid dendritic cell	6 studies	21% ± 4%	Explore
plasma cell	5 studies	27% ± 8%	Explore
mononuclear phagocyte	5 studies	25% ± 11%	Explore
connective tissue cell	5 studies	24% ± 4%	Explore
epithelial cell	5 studies	31% ± 17%	Explore
basal cell	5 studies	25% ± 13%	Explore
naive B cell	5 studies	19% ± 2%	Explore
myofibroblast cell	4 studies	17% ± 2%	Explore
endothelial cell of sinusoid	4 studies	45% ± 32%	Explore
glomerular endothelial cell	3 studies	35% ± 4%	Explore
kidney loop of Henle epithelial cell	3 studies	22% ± 7%	Explore
epithelial cell of proximal tubule	3 studies	17% ± 1%	Explore
ciliated cell	3 studies	19% ± 3%	Explore
Mueller cell	3 studies	18% ± 1%	Explore
GABAergic neuron	3 studies	44% ± 7%	Explore
glutamatergic neuron	3 studies	51% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	28% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	5 studies	21% ± 3%	Explore
brain	5 studies	32% ± 10%	Explore
peripheral blood	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	5076.62	180 / 180	100%	24.12	430 / 430
breast	100%	6951.95	459 / 459	100%	38.13	1116 / 1118
prostate	100%	4372.41	245 / 245	100%	27.12	500 / 502
kidney	100%	7609.34	89 / 89	99%	42.14	895 / 901
brain	99%	3373.31	2624 / 2642	100%	56.32	704 / 705
esophagus	100%	4698.54	1444 / 1445	99%	16.93	181 / 183
skin	100%	7155.58	1809 / 1809	99%	30.93	465 / 472
thymus	100%	5949.30	653 / 653	99%	23.07	596 / 605
lung	100%	5736.94	577 / 578	99%	25.84	1138 / 1155
adrenal gland	100%	8566.90	258 / 258	97%	34.29	223 / 230
bladder	100%	5505.76	21 / 21	97%	21.79	488 / 504
uterus	100%	5686.08	170 / 170	96%	20.77	440 / 459
pancreas	96%	2021.90	315 / 328	99%	22.08	176 / 178
intestine	100%	3600.50	964 / 966	95%	17.00	501 / 527
stomach	99%	2768.03	357 / 359	95%	17.31	271 / 286
liver	98%	2941.04	222 / 226	94%	16.74	380 / 406
adipose	100%	6976.63	1204 / 1204	0%	0	0 / 0
spleen	100%	4709.18	241 / 241	0%	0	0 / 0
blood vessel	100%	4493.36	1331 / 1335	0%	0	0 / 0
heart	98%	4068.39	848 / 861	0%	0	0 / 0
peripheral blood	98%	6511.80	914 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	21.51	44 / 45
eye	0%	0	0 / 0	98%	20.16	78 / 80
lymph node	0%	0	0 / 0	97%	24.53	28 / 29
muscle	35%	447.16	280 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0097009	Biological process	energy homeostasis
GO_0003085	Biological process	negative regulation of systemic arterial blood pressure
GO_0060055	Biological process	angiogenesis involved in wound healing
GO_2000377	Biological process	regulation of reactive oxygen species metabolic process
GO_0043535	Biological process	regulation of blood vessel endothelial cell migration
GO_0006508	Biological process	proteolysis
GO_0002353	Biological process	plasma kallikrein-kinin cascade
GO_0042593	Biological process	glucose homeostasis
GO_0002155	Biological process	regulation of thyroid hormone receptor signaling pathway
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0045178	Cellular component	basal part of cell
GO_0035577	Cellular component	azurophil granule membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0101003	Cellular component	ficolin-1-rich granule membrane
GO_0008239	Molecular function	dipeptidyl-peptidase activity
GO_0004185	Molecular function	serine-type carboxypeptidase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PRCP
Protein name	Prolylcarboxypeptidase (cDNA FLJ33528 fis, clone BRAMY2007110, highly similar to Lysosomal Pro-X carboxypeptidase) Prolylcarboxypeptidase Prolylcarboxypeptidase (cDNA FLJ57232, highly similar to Lysosomal Pro-X carboxypeptidase (EC3.4.16.2)) Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Angiotensinase C) (Lysosomal carboxypeptidase C) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP)
Synonyms	PCP
Description	FUNCTION: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
Accessions	A0A7P0Z451 ENST00000533126.1 ENST00000534264.2 ENST00000532809.2 P42785 ENST00000680566.1 ENST00000528082.6 ENST00000681637.1 ENST00000680186.1 ENST00000679623.1 E9PQB5 ENST00000680040.1 ENST00000531801.6 ENST00000681432.1 ENST00000679809.1 ENST00000681592.1 B3KR26 B7Z7Q6 A0A7P0TB23 ENST00000680524.1 ENST00000529671.5 ENST00000313010.8 [P42785-1] E9PLY4 ENST00000534631.5 E9PL85 E9PNJ1 ENST00000531128.5 ENST00000534396.5 E9PKN6 ENST00000680437.1 ENST00000681883.1 ENST00000393399.6 [P42785-2] E9PL49 ENST00000679387.1 ENST00000681322.1 E9PNF7

PRCP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review