PPP1R9B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PPP1R9B at tissue level.

III. Associated gene sets

GO_1901653Biological processcellular response to peptide
GO_2000474Biological processregulation of opioid receptor signaling pathway
GO_1903119Biological processprotein localization to actin cytoskeleton
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0021766Biological processhippocampus development
GO_0019722Biological processcalcium-mediated signaling
GO_1904373Biological processresponse to kainic acid
GO_0007612Biological processlearning
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0030042Biological processactin filament depolymerization
GO_0031175Biological processneuron projection development
GO_1904386Biological processresponse to L-phenylalanine derivative
GO_0060179Biological processmale mating behavior
GO_0035902Biological processresponse to immobilization stress
GO_0071392Biological processcellular response to estradiol stimulus
GO_0007096Biological processregulation of exit from mitosis
GO_0001560Biological processregulation of cell growth by extracellular stimulus
GO_0071315Biological processcellular response to morphine
GO_1990778Biological processprotein localization to cell periphery
GO_0001932Biological processregulation of protein phosphorylation
GO_0061458Biological processreproductive system development
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_1904372Biological processpositive regulation of protein localization to actin cortical patch
GO_0008380Biological processRNA splicing
GO_0007015Biological processactin filament organization
GO_0034695Biological processresponse to prostaglandin E
GO_0035094Biological processresponse to nicotine
GO_0046847Biological processfilopodium assembly
GO_0048545Biological processresponse to steroid hormone
GO_0001975Biological processresponse to amphetamine
GO_0021987Biological processcerebral cortex development
GO_0016358Biological processdendrite development
GO_0003006Biological processdevelopmental process involved in reproduction
GO_0016477Biological processcell migration
GO_0042127Biological processregulation of cell population proliferation
GO_0051726Biological processregulation of cell cycle
GO_0030308Biological processnegative regulation of cell growth
GO_0032587Cellular componentruffle membrane
GO_0000164Cellular componentprotein phosphatase type 1 complex
GO_1990780Cellular componentcytoplasmic side of dendritic spine plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0030864Cellular componentcortical actin cytoskeleton
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0030175Cellular componentfilopodium
GO_0015629Cellular componentactin cytoskeleton
GO_0005912Cellular componentadherens junction
GO_0014069Cellular componentpostsynaptic density
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0044326Cellular componentdendritic spine neck
GO_0044327Cellular componentdendritic spine head
GO_0030027Cellular componentlamellipodium
GO_0019900Molecular functionkinase binding
GO_0051015Molecular functionactin filament binding
GO_0004672Molecular functionprotein kinase activity
GO_0004864Molecular functionprotein phosphatase inhibitor activity
GO_0008157Molecular functionprotein phosphatase 1 binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0031749Molecular functionD2 dopamine receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPP1R9B
Protein nameNeurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
PPP1R9B protein
SynonymsPPP1R6
DescriptionFUNCTION: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration. .

AccessionsENST00000612501.2
Q96B17
Q96SB3
Q96HI8