PPP1R16B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051489Biological processregulation of filopodium assembly
GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1902309Biological processnegative regulation of peptidyl-serine dephosphorylation
GO_1903670Biological processregulation of sprouting angiogenesis
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0061028Biological processestablishment of endothelial barrier
GO_1903589Biological processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0035308Biological processnegative regulation of protein dephosphorylation
GO_0035307Biological processpositive regulation of protein dephosphorylation
GO_0035304Biological processregulation of protein dephosphorylation
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016607Cellular componentnuclear speck
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0005634Cellular componentnucleus
GO_0004857Molecular functionenzyme inhibitor activity
GO_0017020Molecular functionmyosin phosphatase regulator activity
GO_0019888Molecular functionprotein phosphatase regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPP1R16B
Protein nameProtein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP)
SynonymsANKRD4
KIAA0823
DescriptionFUNCTION: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function . Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation . Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells . Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation . Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 . Involved in the dephosphorylation of EEF1A1 . .

AccessionsENST00000299824.6 [Q96T49-1]
Q96T49
ENST00000373331.2 [Q96T49-2]