Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 14 studies | 21% ± 5% | |
oligodendrocyte | 6 studies | 23% ± 5% | |
endothelial cell of artery | 5 studies | 19% ± 4% | |
astrocyte | 5 studies | 22% ± 5% | |
glutamatergic neuron | 5 studies | 31% ± 8% | |
macrophage | 5 studies | 24% ± 3% | |
microglial cell | 4 studies | 20% ± 5% | |
epithelial cell | 4 studies | 20% ± 3% | |
endothelial cell of vascular tree | 4 studies | 22% ± 7% | |
GABAergic neuron | 4 studies | 27% ± 7% | |
endothelial cell of lymphatic vessel | 4 studies | 19% ± 2% | |
interneuron | 3 studies | 30% ± 11% | |
oligodendrocyte precursor cell | 3 studies | 21% ± 3% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 6 studies | 28% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 1271.56 | 577 / 578 | 100% | 11.08 | 1151 / 1155 |
esophagus | 100% | 984.57 | 1445 / 1445 | 99% | 11.37 | 182 / 183 |
breast | 100% | 1549.78 | 459 / 459 | 99% | 17.18 | 1111 / 1118 |
stomach | 100% | 733.17 | 359 / 359 | 99% | 11.33 | 284 / 286 |
intestine | 100% | 1058.80 | 966 / 966 | 99% | 10.85 | 523 / 527 |
ovary | 100% | 2014.79 | 180 / 180 | 99% | 10.37 | 426 / 430 |
bladder | 100% | 958.76 | 21 / 21 | 99% | 10.97 | 498 / 504 |
thymus | 100% | 1006.20 | 653 / 653 | 99% | 12.48 | 597 / 605 |
prostate | 100% | 1055.13 | 245 / 245 | 99% | 9.69 | 495 / 502 |
uterus | 100% | 1721.00 | 170 / 170 | 98% | 13.74 | 452 / 459 |
skin | 100% | 1027.05 | 1808 / 1809 | 98% | 13.92 | 461 / 472 |
brain | 97% | 856.57 | 2572 / 2642 | 100% | 15.78 | 703 / 705 |
kidney | 100% | 696.85 | 89 / 89 | 97% | 15.74 | 871 / 901 |
pancreas | 98% | 502.74 | 321 / 328 | 98% | 9.33 | 175 / 178 |
adrenal gland | 100% | 740.76 | 258 / 258 | 94% | 8.55 | 216 / 230 |
liver | 99% | 396.48 | 224 / 226 | 86% | 6.38 | 351 / 406 |
adipose | 100% | 1620.59 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 9.26 | 29 / 29 |
spleen | 100% | 1037.72 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 13.03 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.38 | 1 / 1 |
blood vessel | 100% | 897.27 | 1333 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 716.63 | 799 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 492.02 | 842 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 11.03 | 77 / 80 |
peripheral blood | 92% | 829.53 | 855 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0045814 | Biological process | negative regulation of gene expression, epigenetic |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0006470 | Biological process | protein dephosphorylation |
GO_0009314 | Biological process | response to radiation |
GO_0009617 | Biological process | response to bacterium |
GO_0006346 | Biological process | DNA methylation-dependent heterochromatin formation |
GO_0035970 | Biological process | peptidyl-threonine dephosphorylation |
GO_0009267 | Biological process | cellular response to starvation |
GO_0060260 | Biological process | regulation of transcription initiation by RNA polymerase II |
GO_0000086 | Biological process | G2/M transition of mitotic cell cycle |
GO_0030330 | Biological process | DNA damage response, signal transduction by p53 class mediator |
GO_0005730 | Cellular component | nucleolus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005634 | Cellular component | nucleus |
GO_0017018 | Molecular function | myosin phosphatase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0051019 | Molecular function | mitogen-activated protein kinase binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0004722 | Molecular function | protein serine/threonine phosphatase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | PPM1D |
Protein name | Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1) Protein phosphatase, Mg2+/Mn2+ dependent 1D Protein phosphatase 1D magnesium-dependent, delta isoform Protein phosphatase Mg2+/Mn2+ dependent 1D isoform 2 (Protein phosphatase, Mg2+/Mn2+ dependent 1D) Protein phosphatase Mg2+/Mn2+ dependent 1D isoform 1 |
Synonyms | WIP1 |
Description | FUNCTION: Involved in the negative regulation of p53 expression . Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins . Mediates MAPK14 dephosphorylation and inactivation . Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). . |
Accessions | A0A8I5KNX5 ENST00000693196.1 ENST00000693102.1 ENST00000392995.7 [O15297-2] ENST00000305921.8 [O15297-1] A0A8I5KT72 ENST00000689445.1 A0A8I5QJK9 ENST00000629650.3 ENST00000685212.1 Q8NEA7 A0A8I5KUN6 ENST00000688505.1 A0A8I5QKP1 A0A8I5KUX8 ENST00000686064.1 A0A8J9C7E3 O15297 A0A0S2Z4W0 ENST00000687355.1 A0A0S2Z4M2 |