PPM1D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006470Biological processprotein dephosphorylation
GO_0009314Biological processresponse to radiation
GO_0009617Biological processresponse to bacterium
GO_0006346Biological processDNA methylation-dependent heterochromatin formation
GO_0035970Biological processpeptidyl-threonine dephosphorylation
GO_0009267Biological processcellular response to starvation
GO_0060260Biological processregulation of transcription initiation by RNA polymerase II
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0030330Biological processDNA damage response, signal transduction by p53 class mediator
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0017018Molecular functionmyosin phosphatase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0046872Molecular functionmetal ion binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPM1D
Protein nameProtein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)
Protein phosphatase, Mg2+/Mn2+ dependent 1D
Protein phosphatase 1D magnesium-dependent, delta isoform
Protein phosphatase Mg2+/Mn2+ dependent 1D isoform 2 (Protein phosphatase, Mg2+/Mn2+ dependent 1D)
Protein phosphatase Mg2+/Mn2+ dependent 1D isoform 1
SynonymsWIP1
DescriptionFUNCTION: Involved in the negative regulation of p53 expression . Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins . Mediates MAPK14 dephosphorylation and inactivation . Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). .

AccessionsA0A8I5KNX5
ENST00000693196.1
ENST00000693102.1
ENST00000392995.7 [O15297-2]
ENST00000305921.8 [O15297-1]
A0A8I5KT72
ENST00000689445.1
A0A8I5QJK9
ENST00000629650.3
ENST00000685212.1
Q8NEA7
A0A8I5KUN6
ENST00000688505.1
A0A8I5QKP1
A0A8I5KUX8
ENST00000686064.1
A0A8J9C7E3
O15297
A0A0S2Z4W0
ENST00000687355.1
A0A0S2Z4M2