Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipocyte | 8 studies | 25% ± 6% | |
| cardiac muscle cell | 5 studies | 38% ± 8% | |
| endothelial cell | 4 studies | 35% ± 23% | |
| pericyte | 4 studies | 21% ± 3% | |
| retinal bipolar neuron | 3 studies | 30% ± 3% | |
| epithelial cell | 3 studies | 22% ± 4% | |
| rod bipolar cell | 3 studies | 35% ± 7% | |
| GABAergic neuron | 3 studies | 45% ± 9% | |
| glutamatergic neuron | 3 studies | 53% ± 14% | |
| macrophage | 3 studies | 21% ± 3% | |
| transit amplifying cell | 3 studies | 21% ± 4% | |
| microglial cell | 3 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 99% | 1661.83 | 1437 / 1445 | 99% | 6.12 | 182 / 183 |
| intestine | 100% | 3085.32 | 966 / 966 | 97% | 4.51 | 511 / 527 |
| stomach | 99% | 1540.34 | 355 / 359 | 96% | 5.06 | 274 / 286 |
| bladder | 100% | 1901.48 | 21 / 21 | 83% | 2.87 | 417 / 504 |
| skin | 85% | 1057.00 | 1533 / 1809 | 93% | 4.70 | 438 / 472 |
| uterus | 96% | 846.25 | 163 / 170 | 80% | 2.58 | 366 / 459 |
| lung | 100% | 1794.45 | 576 / 578 | 76% | 2.76 | 874 / 1155 |
| ovary | 66% | 311.26 | 119 / 180 | 98% | 6.43 | 422 / 430 |
| prostate | 96% | 936.93 | 234 / 245 | 64% | 1.33 | 320 / 502 |
| brain | 90% | 1053.81 | 2370 / 2642 | 69% | 1.47 | 484 / 705 |
| breast | 93% | 738.25 | 428 / 459 | 63% | 1.48 | 708 / 1118 |
| adrenal gland | 64% | 246.91 | 165 / 258 | 77% | 2.24 | 178 / 230 |
| pancreas | 41% | 147.49 | 134 / 328 | 71% | 1.76 | 126 / 178 |
| liver | 79% | 382.65 | 179 / 226 | 28% | 0.47 | 114 / 406 |
| kidney | 45% | 228.83 | 40 / 89 | 60% | 1.25 | 538 / 901 |
| eye | 0% | 0 | 0 / 0 | 100% | 7.94 | 80 / 80 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.09 | 1 / 1 |
| adipose | 99% | 997.58 | 1187 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 6.39 | 44 / 45 |
| spleen | 98% | 684.57 | 235 / 241 | 0% | 0 | 0 / 0 |
| muscle | 97% | 1204.63 | 779 / 803 | 0% | 0 | 0 / 0 |
| heart | 96% | 1409.21 | 830 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 76% | 2.69 | 22 / 29 |
| thymus | 45% | 160.50 | 295 / 653 | 14% | 0.29 | 87 / 605 |
| blood vessel | 44% | 283.07 | 593 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 27% | 647.37 | 255 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042327 | Biological process | positive regulation of phosphorylation |
| GO_0060346 | Biological process | bone trabecula formation |
| GO_0034614 | Biological process | cellular response to reactive oxygen species |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_0006390 | Biological process | mitochondrial transcription |
| GO_0045672 | Biological process | positive regulation of osteoclast differentiation |
| GO_0007015 | Biological process | actin filament organization |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0001503 | Biological process | ossification |
| GO_0030520 | Biological process | estrogen receptor signaling pathway |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0045780 | Biological process | positive regulation of bone resorption |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0016592 | Cellular component | mediator complex |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005634 | Cellular component | nucleus |
| GO_0008134 | Molecular function | transcription factor binding |
| GO_0003712 | Molecular function | transcription coregulator activity |
| GO_0030331 | Molecular function | nuclear estrogen receptor binding |
| GO_0003723 | Molecular function | RNA binding |
| GO_0050682 | Molecular function | AF-2 domain binding |
| GO_0030374 | Molecular function | nuclear receptor coactivator activity |
| Gene name | PPARGC1B |
| Protein name | Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator) PPARGC1B protein PPARG coactivator 1 beta |
| Synonyms | PERC PGC1B PPARGC1 PGC1 |
| Description | FUNCTION: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. . |
| Accessions | B7ZM40 ENST00000309241.10 [Q86YN6-1] ENST00000360453.8 [Q86YN6-5] ENST00000403750.5 [Q86YN6-6] Q86YN6 ENST00000434684.1 H0Y713 Q8TAL0 ENST00000394320.7 [Q86YN6-3] |