PPARGC1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042327Biological processpositive regulation of phosphorylation
GO_0060346Biological processbone trabecula formation
GO_0034614Biological processcellular response to reactive oxygen species
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0006390Biological processmitochondrial transcription
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0007015Biological processactin filament organization
GO_0006355Biological processregulation of DNA-templated transcription
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0001503Biological processossification
GO_0030520Biological processestrogen receptor signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045780Biological processpositive regulation of bone resorption
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016592Cellular componentmediator complex
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0003723Molecular functionRNA binding
GO_0050682Molecular functionAF-2 domain binding
GO_0030374Molecular functionnuclear receptor coactivator activity

IV. Literature review

[source]
Gene namePPARGC1B
Protein namePeroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC-1-beta) (PPAR-gamma coactivator 1-beta) (PPARGC-1-beta) (PGC-1-related estrogen receptor alpha coactivator)
PPARGC1B protein
PPARG coactivator 1 beta
SynonymsPERC
PGC1B
PPARGC1
PGC1
DescriptionFUNCTION: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. .

AccessionsB7ZM40
ENST00000309241.10 [Q86YN6-1]
ENST00000360453.8 [Q86YN6-5]
ENST00000403750.5 [Q86YN6-6]
Q86YN6
ENST00000434684.1
H0Y713
Q8TAL0
ENST00000394320.7 [Q86YN6-3]