POLN | OmnibusX

Name	Number of supported studies	Average coverage
brain	4 studies	43% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	240.14	245 / 245	34%	0.53	173 / 502
adrenal gland	99%	152.66	255 / 258	19%	0.30	43 / 230
brain	100%	267.61	2638 / 2642	18%	0.28	124 / 705
breast	100%	272.12	459 / 459	15%	0.25	168 / 1118
ovary	100%	121.96	180 / 180	9%	0.15	38 / 430
uterus	99%	121.73	168 / 170	5%	0.11	21 / 459
bladder	100%	92.71	21 / 21	1%	0.03	6 / 504
thymus	100%	118.41	652 / 653	1%	0.01	6 / 605
skin	99%	119.76	1782 / 1809	2%	0.07	10 / 472
spleen	100%	117.57	241 / 241	0%	0	0 / 0
adipose	100%	260.36	1203 / 1204	0%	0	0 / 0
kidney	97%	96.61	86 / 89	2%	0.02	14 / 901
blood vessel	98%	112.75	1309 / 1335	0%	0	0 / 0
stomach	96%	77.36	345 / 359	0%	0.00	1 / 286
intestine	95%	99.10	915 / 966	2%	0.03	8 / 527
lung	94%	86.29	545 / 578	1%	0.02	16 / 1155
esophagus	93%	92.10	1351 / 1445	1%	0.01	1 / 183
pancreas	89%	63.66	293 / 328	1%	0.01	2 / 178
liver	81%	50.94	183 / 226	4%	0.08	16 / 406
muscle	85%	62.84	680 / 803	0%	0	0 / 0
heart	83%	67.62	714 / 861	0%	0	0 / 0
peripheral blood	30%	21.84	275 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0019985	Biological process	translesion synthesis
GO_0036297	Biological process	interstrand cross-link repair
GO_0006261	Biological process	DNA-templated DNA replication
GO_0006302	Biological process	double-strand break repair
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0003887	Molecular function	DNA-directed DNA polymerase activity
GO_0003677	Molecular function	DNA binding
GO_0005515	Molecular function	protein binding
GO_0030332	Molecular function	cyclin binding

Gene name	POLN
Protein name	DNA polymerase nu DNA polymerase nu (EC 2.7.7.7)
Synonyms
Description	FUNCTION: DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template . Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ) . Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity . Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence . May play a role in TLS during interstrand cross-link (ICL) repair . May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents . Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links . .
Accessions	ENST00000511098.1 ENST00000382865.5 [Q7Z5Q5-1] Q7Z5Q5 ENST00000511885.6 [Q7Z5Q5-1] H0YA88

POLN report