Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 47 studies | 41% ± 16% | |
| endothelial cell of lymphatic vessel | 19 studies | 27% ± 8% | |
| capillary endothelial cell | 16 studies | 42% ± 15% | |
| endothelial cell of artery | 13 studies | 48% ± 20% | |
| vein endothelial cell | 11 studies | 26% ± 8% | |
| endothelial cell of vascular tree | 9 studies | 35% ± 20% | |
| mesothelial cell | 7 studies | 45% ± 16% | |
| retinal rod cell | 7 studies | 33% ± 13% | |
| podocyte | 6 studies | 91% ± 6% | |
| retinal cone cell | 5 studies | 30% ± 8% | |
| glutamatergic neuron | 5 studies | 19% ± 3% | |
| glomerular endothelial cell | 4 studies | 67% ± 4% | |
| pericyte | 4 studies | 54% ± 22% | |
| respiratory goblet cell | 3 studies | 21% ± 6% | |
| secretory cell | 3 studies | 38% ± 27% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 10391.98 | 459 / 459 | 97% | 70.29 | 1089 / 1118 |
| pancreas | 100% | 9276.41 | 328 / 328 | 97% | 84.41 | 173 / 178 |
| ovary | 96% | 4178.13 | 173 / 180 | 99% | 113.46 | 426 / 430 |
| brain | 95% | 4909.86 | 2512 / 2642 | 100% | 63.38 | 702 / 705 |
| intestine | 99% | 4567.76 | 953 / 966 | 95% | 46.30 | 500 / 527 |
| thymus | 100% | 13417.98 | 653 / 653 | 90% | 63.09 | 544 / 605 |
| stomach | 94% | 3067.81 | 337 / 359 | 96% | 47.76 | 274 / 286 |
| prostate | 99% | 5146.93 | 242 / 245 | 88% | 28.91 | 443 / 502 |
| lung | 100% | 22299.72 | 578 / 578 | 86% | 36.78 | 994 / 1155 |
| adrenal gland | 99% | 4792.04 | 255 / 258 | 77% | 39.40 | 176 / 230 |
| bladder | 95% | 5213.38 | 20 / 21 | 80% | 30.94 | 403 / 504 |
| kidney | 100% | 46271.34 | 89 / 89 | 75% | 106.76 | 677 / 901 |
| uterus | 99% | 10909.26 | 169 / 170 | 75% | 35.24 | 344 / 459 |
| esophagus | 91% | 3534.09 | 1319 / 1445 | 83% | 39.83 | 152 / 183 |
| skin | 71% | 2825.39 | 1276 / 1809 | 51% | 19.93 | 240 / 472 |
| adipose | 100% | 10830.74 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| heart | 100% | 8257.30 | 861 / 861 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 14.36 | 1 / 1 |
| spleen | 93% | 2335.61 | 225 / 241 | 0% | 0 | 0 / 0 |
| muscle | 87% | 2217.32 | 698 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 81% | 3197.81 | 1081 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 64% | 36.27 | 29 / 45 |
| liver | 7% | 125.17 | 16 / 226 | 54% | 18.10 | 219 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 21% | 4.24 | 6 / 29 |
| eye | 0% | 0 | 0 / 0 | 19% | 4.51 | 15 / 80 |
| peripheral blood | 0% | 1.93 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007162 | Biological process | negative regulation of cell adhesion |
| GO_0033634 | Biological process | positive regulation of cell-cell adhesion mediated by integrin |
| GO_0007155 | Biological process | cell adhesion |
| GO_0072175 | Biological process | epithelial tube formation |
| GO_0032534 | Biological process | regulation of microvillus assembly |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0072015 | Biological process | podocyte development |
| GO_0016477 | Biological process | cell migration |
| GO_0022408 | Biological process | negative regulation of cell-cell adhesion |
| GO_0001726 | Cellular component | ruffle |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005615 | Cellular component | extracellular space |
| GO_0036057 | Cellular component | slit diaphragm |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0034451 | Cellular component | centriolar satellite |
| GO_0045121 | Cellular component | membrane raft |
| GO_0031528 | Cellular component | microvillus membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0030175 | Cellular component | filopodium |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PODXL |
| Protein name | Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1) Podocalyxin like (Podocalyxin-like, isoform CRA_b) Podocalyxin (Podocalyxin-like protein 1) |
| Synonyms | PCLP1 PCLP hCG_18687 |
| Description | FUNCTION: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. . FUNCTION: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. . |
| Accessions | ENST00000446198.5 ENST00000378555.8 [O00592-1] B7ZKQ8 G3V0E6 O00592 ENST00000322985.9 [O00592-2] |