PODXL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007162Biological processnegative regulation of cell adhesion
GO_0033634Biological processpositive regulation of cell-cell adhesion mediated by integrin
GO_0007155Biological processcell adhesion
GO_0072175Biological processepithelial tube formation
GO_0032534Biological processregulation of microvillus assembly
GO_0030335Biological processpositive regulation of cell migration
GO_0072015Biological processpodocyte development
GO_0016477Biological processcell migration
GO_0022408Biological processnegative regulation of cell-cell adhesion
GO_0001726Cellular componentruffle
GO_0016324Cellular componentapical plasma membrane
GO_0005730Cellular componentnucleolus
GO_0005615Cellular componentextracellular space
GO_0036057Cellular componentslit diaphragm
GO_0005886Cellular componentplasma membrane
GO_0034451Cellular componentcentriolar satellite
GO_0045121Cellular componentmembrane raft
GO_0031528Cellular componentmicrovillus membrane
GO_0070062Cellular componentextracellular exosome
GO_0030175Cellular componentfilopodium
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030027Cellular componentlamellipodium
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePODXL
Protein namePodocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)
Podocalyxin like (Podocalyxin-like, isoform CRA_b)
Podocalyxin (Podocalyxin-like protein 1)
SynonymsPCLP1
PCLP
hCG_18687
DescriptionFUNCTION: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. .

FUNCTION: Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. .

AccessionsENST00000446198.5
ENST00000378555.8 [O00592-1]
B7ZKQ8
G3V0E6
O00592
ENST00000322985.9 [O00592-2]