PMEPA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030521Biological processandrogen receptor signaling pathway
GO_0060392Biological processnegative regulation of SMAD protein signal transduction
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0031901Cellular componentearly endosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070412Molecular functionR-SMAD binding
GO_0140311Molecular functionprotein sequestering activity
GO_0005515Molecular functionprotein binding
GO_0050699Molecular functionWW domain binding

IV. Literature review

[source]
Gene namePMEPA1
Protein nameProstate transmembrane protein, androgen induced 1
Protein TMEPAI (Prostate transmembrane protein androgen induced 1) (Solid tumor-associated 1 protein) (Transmembrane prostate androgen-induced protein)
SynonymsSTAG1
TMEPAI
DescriptionFUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal . Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 . .

AccessionsA2A2F5
Q66K30
Q969W9
ENST00000265626.8 [Q969W9-3]
ENST00000414037.5
ENST00000395814.5 [Q969W9-3]
ENST00000395816.7 [Q969W9-3]
ENST00000341744.8 [Q969W9-1]
ENST00000347215.8 [Q969W9-2]
A2A2F4
ENST00000395819.3