PHAX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043489Biological processRNA stabilization
GO_0015031Biological processprotein transport
GO_0006408Biological processsnRNA export from nucleus
GO_0015030Cellular componentCajal body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_1990904Cellular componentribonucleoprotein complex
GO_0043025Cellular componentneuronal cell body
GO_0005634Cellular componentnucleus
GO_0140262Molecular functionmRNA cap binding complex binding
GO_0015643Molecular functiontoxic substance binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePHAX
Protein namePhosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein)
SynonymsRNUXA
DescriptionFUNCTION: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. .

AccessionsQ9H814
ENST00000297540.5