PFKL | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	19 studies	24% ± 9%	Explore
endothelial cell	19 studies	25% ± 9%	Explore
non-classical monocyte	14 studies	31% ± 13%	Explore
B cell	13 studies	24% ± 7%	Explore
epithelial cell	13 studies	34% ± 19%	Explore
plasmacytoid dendritic cell	11 studies	24% ± 7%	Explore
regulatory T cell	11 studies	20% ± 4%	Explore
conventional dendritic cell	10 studies	26% ± 15%	Explore
classical monocyte	10 studies	23% ± 11%	Explore
naive B cell	10 studies	23% ± 5%	Explore
CD4-positive, alpha-beta T cell	8 studies	21% ± 4%	Explore
fibroblast	8 studies	22% ± 7%	Explore
dendritic cell	8 studies	30% ± 15%	Explore
monocyte	7 studies	20% ± 4%	Explore
astrocyte	7 studies	28% ± 9%	Explore
goblet cell	7 studies	21% ± 7%	Explore
enterocyte	6 studies	27% ± 7%	Explore
abnormal cell	6 studies	30% ± 13%	Explore
precursor B cell	6 studies	31% ± 9%	Explore
pericyte	6 studies	21% ± 4%	Explore
endothelial cell of lymphatic vessel	6 studies	22% ± 6%	Explore
memory B cell	6 studies	19% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	20% ± 3%	Explore
kidney loop of Henle epithelial cell	5 studies	27% ± 8%	Explore
epithelial cell of proximal tubule	5 studies	22% ± 7%	Explore
endothelial cell of artery	5 studies	20% ± 5%	Explore
transit amplifying cell	5 studies	30% ± 8%	Explore
smooth muscle cell	5 studies	19% ± 3%	Explore
myeloid cell	5 studies	26% ± 9%	Explore
basal cell	5 studies	28% ± 10%	Explore
capillary endothelial cell	5 studies	23% ± 9%	Explore
natural killer cell	5 studies	22% ± 4%	Explore
CD8-positive, alpha-beta T cell	5 studies	17% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	30% ± 13%	Explore
retinal ganglion cell	4 studies	76% ± 19%	Explore
pro-B cell	4 studies	29% ± 3%	Explore
immature B cell	4 studies	29% ± 13%	Explore
retinal cone cell	4 studies	28% ± 9%	Explore
retinal pigment epithelial cell	4 studies	39% ± 20%	Explore
ciliated cell	4 studies	27% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	23% ± 5%	Explore
endothelial cell of vascular tree	4 studies	19% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 5%	Explore
oligodendrocyte	4 studies	21% ± 4%	Explore
plasmablast	3 studies	54% ± 4%	Explore
T cell	3 studies	27% ± 9%	Explore
hematopoietic precursor cell	3 studies	28% ± 7%	Explore
connective tissue cell	3 studies	18% ± 4%	Explore
neuron	3 studies	28% ± 9%	Explore
glutamatergic neuron	3 studies	33% ± 13%	Explore
retinal bipolar neuron	3 studies	23% ± 7%	Explore
common myeloid progenitor	3 studies	22% ± 8%	Explore
progenitor cell	3 studies	22% ± 2%	Explore
intermediate monocyte	3 studies	31% ± 14%	Explore
oligodendrocyte precursor cell	3 studies	22% ± 5%	Explore
enteroendocrine cell	3 studies	27% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	22% ± 10%	Explore
kidney	6 studies	18% ± 2%	Explore
lung	6 studies	22% ± 3%	Explore
intestine	5 studies	24% ± 8%	Explore
eye	4 studies	25% ± 6%	Explore
brain	4 studies	28% ± 5%	Explore
placenta	3 studies	22% ± 2%	Explore
liver	3 studies	26% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9946.55	1445 / 1445	100%	70.76	183 / 183
brain	100%	9745.85	2640 / 2642	100%	87.01	705 / 705
ovary	100%	7783.45	180 / 180	100%	77.29	428 / 430
pancreas	100%	4675.51	328 / 328	99%	72.95	177 / 178
intestine	100%	11957.37	966 / 966	99%	107.42	524 / 527
prostate	100%	11197.11	245 / 245	99%	78.72	499 / 502
skin	100%	11931.72	1809 / 1809	99%	92.10	469 / 472
uterus	100%	9069.21	170 / 170	99%	83.02	456 / 459
thymus	100%	9955.40	653 / 653	99%	62.40	601 / 605
kidney	100%	18089.51	89 / 89	99%	109.08	894 / 901
bladder	100%	10884.62	21 / 21	99%	102.99	498 / 504
liver	100%	7766.81	226 / 226	99%	56.30	401 / 406
lung	100%	9826.41	577 / 578	99%	72.61	1141 / 1155
stomach	100%	9240.30	359 / 359	99%	90.07	282 / 286
breast	100%	10891.49	459 / 459	98%	72.78	1101 / 1118
adrenal gland	100%	6750.66	258 / 258	94%	49.22	216 / 230
adipose	100%	10870.66	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	140.33	80 / 80
lymph node	0%	0	0 / 0	100%	108.08	29 / 29
spleen	100%	12157.51	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	99.49	45 / 45
ureter	0%	0	0 / 0	100%	52.81	1 / 1
blood vessel	100%	9162.15	1334 / 1335	0%	0	0 / 0
heart	99%	5065.00	852 / 861	0%	0	0 / 0
peripheral blood	96%	8427.75	892 / 929	0%	0	0 / 0
muscle	59%	1440.27	473 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009749	Biological process	response to glucose
GO_0006096	Biological process	glycolytic process
GO_0006002	Biological process	fructose 6-phosphate metabolic process
GO_0046676	Biological process	negative regulation of insulin secretion
GO_0061621	Biological process	canonical glycolysis
GO_0030388	Biological process	fructose 1,6-bisphosphate metabolic process
GO_0005945	Cellular component	6-phosphofructokinase complex
GO_0005576	Cellular component	extracellular region
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0034774	Cellular component	secretory granule lumen
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005829	Cellular component	cytosol
GO_0019900	Molecular function	kinase binding
GO_0048029	Molecular function	monosaccharide binding
GO_0003872	Molecular function	6-phosphofructokinase activity
GO_0016208	Molecular function	AMP binding
GO_0042802	Molecular function	identical protein binding
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0070061	Molecular function	fructose binding
GO_0070095	Molecular function	fructose-6-phosphate binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PFKL
Protein name	PFKL protein 6-phosphofructokinase type B (Phosphofructo-1-kinase isozyme B) ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase) Phosphofructokinase, liver type
Synonyms
Description	FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis . Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity). .
Accessions	F8WEU2 P17858 ENST00000628044.1 Q9BSP4 ENST00000349048.9 [P17858-1] Q7L2M7 ENST00000397961.6

PFKL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review